Optimizing Aerobic Fitness in Older Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: HIIT, MICT.
- Who it may be relevant to
- Registry conditions: Aerobic Capacity, High Intensity Interval Training. Basic parameters: from 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Optimizing Aerobic Fitness and Functional Response to Exercise in Older Adults
Overview
Hospitalization and treatment for cardiovascular disease is one of the main contributors to disability in older adults. Moderate intensity continuous aerobic and resistance training have been the cornerstone of cardiac rehabilitation (CR) for decades to remediate hospital-acquired functional deficits, but some groups receive less or minimal functional benefit from this training. The proposed studies seek to optimize recovery of aerobic fitness and physical function among older cardiac patients using a novel high intensity training regimen with the long-term goal of reducing subsequent disability and improving clinical outcomes.
Detailed description
Clinical events and hospitalization often initiate disability in older adults with cardiovascular disease (CVD) being the primary cause of hospital acquired disability. Cardiac rehabilitation (CR) was designed to correct this disability, with moderate intensity, continuous aerobic training (MICT) as its foundation but some patients, including older adults, receive less functional benefit from MICT. Attention has recently focused on high intensity interval aerobic training (HIIT) as an alternative to MICT because it improves aerobic fitness to a greater extent and is safe and feasible for older adults enrolled in CR; however, neither HIIT nor MICT address age-related atrophy and weakness. Resistance training is a core component of CR meant to correct these deficits, but the moderate intensity resistance training (MIRT) most commonly used has minimal effects on these outcomes. Thus, there is an unmet clinical need for multi-modal exercise interventions that address the unique needs of older adult patients enrolled in CR to optimize improvements in functional recovery and clinical outcomes.
The investigators will conduct the first direct comparison of HIIT+HIRT to MICT+MIRT to improve VO2peak and physical function in older men and women enrolled in CR.
Aim 1: Determine the efficacy of combined HIIT+HIRT vs MICT+MIRT to increase VO2peak in older adult patients enrolled in CR Aim 2: Determine the efficacy of combined HIIT+HIRT vs MICT+MIRT to increase physical function in older adult patients enrolled in CR.
Interventions
- Other HIIT
Patients who recently experienced a myocardial infarction (MI) or percutaneous intervention (PCI; angioplasty, stent placement or valve replacement) and enroll in Phase 2 Cardiac Rehabilitation (CR) may be randomized to High intensity training (HIIT) - Other MICT
Patients who recently experienced a myocardial infarction (MI) or percutaneous intervention (PCI; angioplasty, stent placement or valve replacement) and enroll in Phase 2 Cardiac Rehabilitation (CR) may be randomized to Moderate intensity training
Primary outcome measures
- Change in Aerobic fitness [Time frame: Within 4 months of the intake assessment]
- Change in 30 sec sit-to-stand test (STS) [Time frame: Within 4 months of the intake assessment]
Secondary outcome measures (8)
- Changes in Quality of Life- Cardiac Specific [Time frame: Within 4 months of the intake assessment]
- Changes in Depressive Symptoms [Time frame: Within 4 months of the intake assessment]
- Changes in Executive Function (digit span) [Time frame: Within 4 months of the intake assessment]
- Changes in Executive Function (BRIEF) [Time frame: Within 4 months of the intake assessment]
- Changes in Executive Function (trail making) [Time frame: Within 4 months of the intake assessment]
- Changes in Physical Function (Six Minute Walk Test) [Time frame: Within 4 months of the intake assessment]
- Changes in Enjoyment of Exercise (PACES) [Time frame: Within 4 months of the intake assessment]
- Changes in Anxiety [Time frame: Within 4 months of the intake assessment]
Eligibility criteria
Inclusion criteria
- >65 years old
- ambulatory
- enrolled in CR at our center following a recent clinical diagnosis of myocardial infarction or percutaneous intervention will be recruited
Exclusion criteria
- have an active malignancy (excluding non-melanoma skin cancer or low grade prostate cancer under surveillance)
- unwilling to comply with the exercise prescription they may be assigned to
- have a submaximal performance on entry exercise tolerance test, defined as respiratory exchange ratio <1.0
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Treatment
Study locations
United States · 1 center
- UVMMC Cardiac Rehabilitation — South Burlington
Identifiers
NCT: NCT06951620 · #STUDY00002693 · R01AG084636