Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: CT coronary angiography.
- Who it may be relevant to
- Registry conditions: Atrial Fibrillation (AF). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions this study aims to answer are: 1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)
Interventions
- Diagnostic test CT coronary angiography
To assess the presence of obstructive coronary artery disease, participants will either have coronary angiography as part of their routine care or they will return for a research CT scan of their heart (CT Coronary Angiogram)
Primary outcome measures
- Presence of obstructive coronary artery disease [Time frame: within 4 weeks of presentation]
Secondary outcome measures (1)
- Imaging evidence of new myocardial infarction [Time frame: within 4 weeks of presentation]
Eligibility criteria
Inclusion criteria
- Age 18 years and over
- Primary presentation with symptoms related to atrial fibrillation
- Atrial fibrillation with a ventricular rate >100 bpm on a 12-lead electrocardiogram
- Able to provide informed consent
Exclusion criteria
- Previous myocardial infarction
- Previous coronary revascularisation procedure
- Patients in renal failure (eGFR <30ml/min/1.73m2) or major allergy to contrast media
- Pregnancy or breast feeding
- Deemed unsuitable for participation in the study by the attending clinician
- Previous enrolment in the trial
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United Kingdom · 1 center
- Royal Infirmary of Edinburgh — Edinburgh
Identifiers
NCT: NCT06951100 · AC24081 · 25-SS-0009