Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: observational study.
- Who it may be relevant to
- Registry conditions: Cirrhosis, Intensive Care Medicine, Acute on Chronic Liver Failure(ACLF). Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess the impact of these changes on the prognosis of these patients. The following hypotheses will be tested: * Improvement in intensive care and overall prognosis compared with data from the literature prior to 2014 * Improved access to liver transplantation compared with the literature prior to 2014 * Improvement in intensive care unit practices (for example: application of recommendations published by learned societies concerning the intensive care unit management of patients with cirrhosis, access to comfort care, degree of clinical severity on admission to the intensive care unit, etc.). * Centre' effect: variability in the phenotype of patients admitted to intensive care depending on the technical facilities available and whether or not the hospital centre has access to TH.
Interventions
- Other observational study
This observational study aims to describe the clinical practices and the outcome of patients admitted in ICU.
Primary outcome measures
- 28-day survival [Time frame: 28 days]
Secondary outcome measures (7)
- Phenotype of patients admitted to intensive care [Time frame: baseline]
- Overall survival [Time frame: through study completion]
- Survival without liver transplantation [Time frame: 12 months]
- Proportion of patients listed for liver transplantation [Time frame: through study completion]
- number of patients receiving LT [Time frame: through study completion]
- Prognostic performance of general and cirrhosis-specific organ failure scores [Time frame: baseline]
- Comparison of the characteristics of patients on admission in primary care hospitals and in university hospital. [Time frame: baseline]
Eligibility criteria
Inclusion criteria
Patients with cirrhosis over 18 years of age (cirrhosis either histologically proven or diagnosed by hepatologists according to clinical, biological and ultrasound criteria) admitted to intensive care between January 2014 and December 2024.
Exclusion criteria
None
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- CHU de Besançon — Besançon
Identifiers
NCT: NCT06948565 · 2024/908