the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Hyaluronic Acid (HA), platlet rich plasma (PRP).
- Who it may be relevant to
- Registry conditions: Infertile Patients. Basic parameters: 18 years — 40 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Iraq
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
the Effect of Hyaluronic Acid Platelets Rich Plasma on the Endometrial Receptivity and Intracytoplasmic Sperms Injection Outcome
Overview
Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval. endometrial receptivity parameters, including the subendometrial vasculature indices were measured before and after the intervention for purpose of studying the effect of hyaluronic acid on improvement of the endometrial receptivity and subsequently the pregnancy outcome
Interventions
- Drug Hyaluronic Acid (HA)
hyaluronic acid PRP preparation used to wash the endometrium on the day of oocytes retrieval - Drug platlet rich plasma (PRP)
PRP preparation used to wash the uterine cavity on the day of oocytes retrieval
Primary outcome measures
- measuring the value of resistance index (RI) of the sub-endometrial blood vessels [Time frame: for each participant twice measure will be done for (RI). The first measure will be performed on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.]
- measuring the value of sub- endometrial vessels pulsatile index (PI) [Time frame: for each participant twice measure will be done for PI. The first measure is on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.]
- measuring the value of peak systolic to end diastolic ratio (S/D) of the sub-endometrial blood vessels [Time frame: for each participant twice measure will be done for S/D. The first measure is on the day of oocyte retrieval and the second measure on the day of embryo transfer which is done 3-5 days after oocyte retrieval.]
Secondary outcome measures (1)
- measuring serum level of beta human chorionic gonadotropin [Time frame: 2 weeks from the day of oocyte retrieval]
Eligibility criteria
Inclusion criteria
- Infertile females aged 18-40 years.
- Infertile females scheduled for GnRH antagonist protocol of fresh ICSI cycle.
- Females use dual stimulation (GnRH agonist plus Ovetrelle) for ovulation triggering.
Exclusion criteria
- Infertile females diagnosed as a poor responder.
- Infertile females diagnosed with uterine pathology.
- Infertile females who are scheduled for a frozen ICSI cycle.
- Infertile females diagnosed with endocrine diseases like thyroid disease, diabetes mellitus, and hyperprolactinemia.
- Infertile females diagnosed with thrombocytopenia.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Iraq · 1 center
- high institute for infertility diagnosis and ARTS — AL-Kadimya
Identifiers
NCT: NCT06937645 · 0701-PF-2023G12