Attentional Capture by Real-life Episodic Information
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Old vs new objects" encoding phase and fMRI, " incongruent vs. congruent contexts " encoding phase and fMRI.
- Who it may be relevant to
- Registry conditions: Healthy Volunteers, Attentional Capture. Basic parameters: 18 years — 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Attention facilitates the allocation of processing resources and the control of behavior among competing stimuli. Current research focuses primarily on attention control networks in the dorsal frontoparietal (DAN) and ventral (VAN) cortex. However, typical laboratory experiments emphasize task-specific processing, neglecting the possible role of memory. Although a few studies have examined the contribution of memory to attention control, they have generally used simple tasks in the laboratory. These tasks are unlikely to produce true traces of episodic memory, which are - by definition - characterized by complex contextual information (what, where, when) and personal relevance. This research will therefore use an innovative protocol based on mobile phone technology to generate episodes in the participants' real lives and then measure the impact of these past personal experiences on attention allocation (by assessing eye movements) and on the activity of the DAN/VAN system (using functional imaging). The main hypothesis of the study is that knowledge acquired during everyday life contributes to the subsequent allocation of processing resources, via engagement of the DAN/VAN attention systems.
Interventions
- Behavioral Old vs new objects" encoding phase and fMRI
During the encoding phase, a set of 60 objects will be presented to the participants in their everyday life. Pictures of objects sent to their app mobile phone over a period of 3 weeks. The following week, participants will have an fMRI. During fMRI, participants will see objects already seen or not seen during the encoding phase. - Behavioral " incongruent vs. congruent contexts " encoding phase and fMRI
During the encoding phase, a set of 60 objects will be presented to the participants in their everyday life. Pictures of objects sent to their app mobile phone over a period of 3 weeks. This time, the objects will be chosen according to the participant's location. The following week, participants will have an fMRI. During fMRI, participants will see objects encoding in congruent/incongruent contexts.
Primary outcome measures
- activation pattern in fMRI: "old vs. new" objects (intervention 1) [Time frame: One time during the week after the 3 weeks encoding phase]
Secondary outcome measures (2)
- activation pattern in fMRI: "place" images in intervention 1 [Time frame: One time during the week after the 3 weeks encoding phase]
- activation pattern in fMRI: incongruent vs. congruent contexts (intervention 2) [Time frame: One time during the week after the 3 weeks encoding phase]
Eligibility criteria
Inclusion criteria
- Be 18 years old to 40 years old
- Be right-handed
- Do not wear glasses
- Have a mobile-phone compatible with the application, minimum 6rd generation Android operating system, with geo-localization activated and accepted by the user
- Undertake to comply with the instructions and recommendations for MRI examination
- Provide informed written consent to participate in the study
Exclusion criteria
- History of known neurological or psychiatric illness
- Cognitive problems limiting the understanding of instructions
- Recent taking psychotropic drugs (antidepressants, anxiolytics, antipsychotics). The main treatments not authorized during this research are the following: Psychotropic treatments (drugs that can induce changes in perception, sensation, mood, consciousness or behavior). Like what:
- Antipsychotics (valproic acid, amisulpride, aripiprazole, clozapine, cyamemazin, haloperidol, loxapine, olanzapine, risperidone).
- Antidepressants (Amitriptyline, Citalopram, Clomipramine, Duloxetine, Escitalopam, Fluoxetine, Mianserine, Mirtazapine, Nortriptyline, Paroxetine, Sertraline, Venlafaxine).
- Anxyolitics
- Pregnant or breastfeeding women
- Persons deprived of their liberty by a judicial or administrative decision
- Persons admitted to a health or social institution for purposes other than research
- Adults subject to a legal protection measure (guardianship, curatorship)
- Persons not affiliated to a social security scheme or beneficiaries of a similar scheme
- Participation in another research study of the current study
- Contraindication for fMRI scanning
- Participant not agreeing to be informed in the event of the incidental discovery of an anomaly on MRI
- For visit number 2 :
- Alcohol consumption (> 3 drinks) in the 24h before the experiment
- Alcohol consumption the day of the experiment
- Cafeine consumption 1 hour or less before the experiment
- Drug consumption within the 24h preceding the experiment
- Antimalarial treatment within the 3 days preceding the experiment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
France · 1 center
- UCBL1, CRNL Inserm U1028, CNRS UMR5292, équipe IMPACT — Bron
Identifiers
NCT: NCT06934902 · 69HCL25_0108