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Not yet recruiting NCT06924294

Pattern and Short Term Outcomes of Renal Affection in Patients With Liver Cirrhosis in Al-Rajhi Liver Hospital

— Observational Liver Cirrhosis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: observation of renal affection in patients with liver cirrhosis.
Who it may be relevant to
Registry conditions: Liver Cirrhosis. Basic parameters: No limits · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Egypt
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

* To characterize the pattern and the prevalence of renal affection among liver cirrhosis patients. * To evaluate the short-term outcomes of those patients.

Detailed description

Liver cirrhosis is a chronic liver disease characterized by significant scarring and dysfunction. One of its common complications is renal affection , which can significantly impact patient outcomes .

Aetiology of AKI can be categorized into three main types. These are prerenal (results from decreased renal perfusion), intrinsic renal (acute tubular necrosis), and postrenal AKI. In patients on admission, acute tubular necrosis is a common type of intrinsic AKI .

The development of portal hypertension in patients with liver cirrhosis leading to a reduction in systemic vascular resistance as a result of primary arterial vasodilation in the splanchnic circulation is the primary cause of AKI in cirrhotics. This mechanism primarily leads to hepatorenal syndrome. In addition, the underlying causes of liver cirrhosis can be the cause of intrinsic renal disease .

Early identification and management of AKI may improve outcomes. AKI in patients with liver cirrhosis in Egypt and their impact on inpatient mortality are largely unknown. This study was aimed at determining the prevalence, precipitating factors, predictors, and in-hospital mortality of AKI in patients with liver cirrhosis admitted at Al-Rajhi liver hospital at Egypt .

Interventions

  • Other observation of renal affection in patients with liver cirrhosis
    * CBC * Liver function test * kidney function test (serum creatinine, BUN, eGFR (EPI equation and MDRD equation) , * Prothrombin time and concentration, INR, * Serum electrolytes * Urine analysis.

Primary outcome measures

  • In-hospital mortality [Time frame: Through the study completion , average 6 months]
  • Phenotypes of acute kidney injury across geographic areas [Time frame: Baseline ( at admission ), then through the study completion, average 6 months]
Secondary outcome measures (3)
  • 28-day mortality [Time frame: 28 days]
  • Resolution of AKI [Time frame: Hospital stay (up to 90 days)]
  • Development of CKD [Time frame: 90 days]

Eligibility criteria

Inclusion criteria

  • Patients with liver cirrhosis admitted to the department .

Exclusion criteria

  • Patients with known preexisting chronic kidney disease according to KDIGO and EASL 2018 definitions ( defined as functional GFR <60 ml/min per 1.73 m 2 for ≥3 months or structural kidney damage for ≥3 months ).
  • Patient refusal to give informed consent ( or his first degree relatives in case of disturbed conscious level).

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Egypt · 1 center
  • Al-Raghi liver hospital — Asyut

Publications

  • Choi YJ, Kim JH, Koo JK, Lee CI, Lee JY, Yang JH, Ko SY, Choe WH, Kwon SY, Lee CH. Prevalence of renal dysfunction in patients with cirrhosis according to ADQI-IAC working party proposal. Clin Mol Hepatol. 2014 Jun;20(2):185-91. doi: 10.3350/cmh.2014.20.2.185. Epub 2014 Jun 30. PMID 25032185
  • Duah A, Nkrumah KN. Prevalence and predictors for spontaneous bacterial peritonitis in cirrhotic patients with ascites admitted at medical block in Korle-Bu Teaching Hospital, Ghana. Pan Afr Med J. 2019 May 16;33:35. doi: 10.11604/pamj.2019.33.35.18029. eCollection 2019. PMID 31384350

Identifiers

NCT: NCT06924294 · liver cirrhosis

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗