Bioavailability From Chickpea Meals in Ileostomists?
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Intact chickpeas, Broken chickpeas.
- Who it may be relevant to
- Registry conditions: Nutrition, Absorption, Polyphenolic Compounds and Metabolism, Polyphenols Absorption Profile. Basic parameters: 18 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Bioavailability of Macronutrients and Bioactive Compounds From Chickpea Meals: an Ileostomy Study.
Overview
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells. These cell walls are a barrier for the digestive system to break down completely, which can make it harder to digest the food and get energy from it. This study will explore how the integrity of plant cell walls affects how well humans can absorb macronutrients (protein, fat and carbohydrates) and beneficial compounds e.g. phytochemicals. The study will compare two chickpea meals that have similar nutrients and energy content but differ in the amount of intact plant cell walls e.g. chickpea salad meal (INTACT diet) and chickpea burger meal (BROKEN diet).
Detailed description
The energy content of food can be in principle calculated by multiplying the content of each energy-yielding substrate by the corresponding heat of combustion. However, only part of this energy yielding substrates is converted to energy because of their incomplete digestion and absorption in the gastrointestinal tract. The structural composition of foods, known as the food matrix, significantly affects nutrient bioavailability. One such structural feature is the integrity of plant tissues characterised by the interconnected, continuous network of cell walls which surround and protect plant cells. When cellular integrity is retained, macronutrients are naturally "encapsulated" within cell walls which effectively reduces the rate and the extent of their digestibility by 6-7% compared to a diet poor in plant-based foods. This study aims to investigate the effect of plant tissue integrity on the total energy excretion of a diet, bioavailability of macronutrients and bioactive compounds, and on plasma levels of glucose, essential amino acids and triglycerides. The investigators will do this by comparing two diets which have (approximately) the same composition in macronutrients and energy but different levels of plant tissues integrity, namely a diet rich in intact plant tissues (INTACT diet), and a diet poor in such intact plant tissues (BROKEN diet). The investigators will use an ileostomy model to be able to determine the difference in energy excretion at the level of the terminal ileum.
Interventions
- Other Intact chickpeas
Salad meal containing intact chickpeas - Other Broken chickpeas
Burger meal containing chickpea flour
Primary outcome measures
- Ileal fluid energy content [Time frame: Change over 8 hours comparison between treatments]
Secondary outcome measures (12)
- Ileal fluid macronutrient content [Time frame: Change over 8 hours comparison between treatments]
- Ileal fluid alkylresorcinol content [Time frame: Change over 8 hours comparison between treatments]
- Ileal fluid carotenoid content [Time frame: Change over 8 hours comparison between treatments]
- Circulating glucose concentration [Time frame: Change over 8 hours comparison between treatments]
- Urinary phenolic content [Time frame: Change over 8 hours comparison between treatments]
- Circulating insulin, levels [Time frame: Change over 8 hours comparison between treatments]
- Circulating essential amino acid levels [Time frame: Change over 8 hours comparison between treatments]
- Circulating triglyceride levels [Time frame: Change over 8 hours comparison between treatments]
- Circulating levels of GLP-1 [Time frame: Change over 8 hours comparison between treatments]
- Circulating levels of GIP [Time frame: Change over 8 hours comparison between treatments]
- Circulating levels of ghrelin [Time frame: Change over 8 hours comparison between treatments]
- Circulating levels of CKK [Time frame: Change over 8 hours comparison between treatments]
Eligibility criteria
Inclusion criteria
- Previously had an ileostomy
- ≥1.5-years post-operative
- Aged 18-60 years
- Males and females (not currently pregnant/lactating)
- Non-smokers
- Not allergic to nuts and celery
Exclusion criteria
- Never had an ileostomy
- <1.5-year post-operative
- Not aged 18-60 years
- Pregnant/lactating female
- Smokers
- Allergic to nuts and celery
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Single blind
- Primary purpose
- Other
Study locations
United Kingdom · 1 center
- Human Intervention Studies Unit, Ulster University — Coleraine
Identifiers
NCT: NCT06921811 · REC/24/0083