The Physiological Effect of RCexp on Ventilation/Perfusion Distribution
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: RCexp.
- Who it may be relevant to
- Registry conditions: Acute Respiratory Distress Syndrome, Mechanical Ventilation. Basic parameters: from 19 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Physiological Effect of RCexp on Ventilation/Perfusion Distribution in Patients With ARDS
Overview
With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.
Detailed description
With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.
Interventions
- Other RCexp
patients received different RCexp
Primary outcome measures
- Difference in ventilation/perfusion mismatch [Time frame: 4 hours]
Secondary outcome measures (2)
- Difference in dead space [Time frame: 4 hours]
- Difference in shunt [Time frame: 4 hours]
Eligibility criteria
Inclusion criteria
adult patients with ARDS receiving mechanical ventilation no more than 72 hours
Exclusion criteria
- age <18 years old
- patient undergoing legal protection
- contra-indications to EIT (e. g. severe chest trauma or wounds)
- pneumothorax
- patient undergoing ECMO
- pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-crossover
Study locations
China · 1 center
- Zhongda Hospital, School of Medicine, Southeast University — Nanjing
Identifiers
NCT: NCT06919484 · RCexp_ventilation/perfusion