Hypoxia, Appetite, and Energy Intake in Young Female Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Normoxia, Hypoxia (simulated altitude of 5000 meters above sea-level).
- Who it may be relevant to
- Registry conditions: Hypoxia, Altitude, Appetite, Energy Intake. Basic parameters: 18 years — 30 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Appetite and Energy Intake in Young Female Adults During and After Simulated High-Altitude
Overview
The goal of this clinical trial is to investigate the effects of acute passive continuous hypoxemia (simulated high-altitude at rest) on appetite and energy intake in healthy young female adults. The main questions it aims to answer are: * Does six hours of simulated high-altitude (5000 meters) reduce scores of subjective appetite and energy intake? * Do changes in appetite and energy intake persist in the hours following the end of hypoxic exposure? Researchers will compare the effects of simulated high-altitude to a control normoxia (sea-level) condition to see if exposure to low oxygen levels independently affect appetite and energy intake. Participants will: * Visit the laboratory for a preliminary screening session to assess eligibility. * Undergo two randomized, single-blind, experimental sessions consisting of six hours of passive exposure to normoxia or hypoxia in a climate-controlled chamber. * Consume foods provided from a curated list, served in ad libitum quantities, after leaving the laboratory to assess post-exposure energy intake.
Interventions
- Other Normoxia
Participants will undergo a 6-hour passive exposure to normoxia in a climate-controlled environmental chamber maintained at 22°C with 30% relative humidity. They will remain in a fasted state throughout the exposure period. - Other Hypoxia (simulated altitude of 5000 meters above sea-level)
Participants will undergo a 6-hour passive exposure to a simulated altitude of 5000 meters above sea-level in a climate-controlled environmental chamber maintained at 22°C with 30% relative humidity. They will remain in a fasted state throughout the exposure period.
Primary outcome measures
- Change from baseline in desire to eat [Time frame: Baseline and 6 hours; Baseline and 24 hours]
- Change from baseline in hunger [Time frame: Baseline and 6 hours; Baseline and 24 hours]
- Change from baseline in fullness [Time frame: Baseline and 6 hours; Baseline and 24 hours]
- Change from baseline in prospective food consumption [Time frame: Baseline and 6 hours; Baseline and 24 hours]
- Energy intake immediately after 6 hours of exposure (buffet) [Time frame: Hour 6 of exposure]
- Energy intake post-buffet [Time frame: 6.5 hours of exposure and 24 hours]
Secondary outcome measures (12)
- Heart rate [Time frame: 6 hours]
- Oxyhemoglobin saturation [Time frame: 6 hours]
- Systolic blood pressure [Time frame: 6 hours]
- Diastolic blood pressure [Time frame: 6 hours]
- Lake Louise Acute Mountain Sickness Score [Time frame: 6 hours]
- Fluid consumption during exposure [Time frame: 6 hours]
- Fluid loss during exposure [Time frame: 6 hours]
- Change from baseline in explicit liking using the LFPQ [Time frame: Baseline and 6.5 hours of exposure]
- Change from baseline in explicit wanting using the LFPQ [Time frame: Baseline and 6.5 hours of exposure]
- Change from baseline in implicit wanting using the LFPQ [Time frame: Baseline and 6.5 hours of exposure]
- Change from baseline in olfaction [Time frame: Baseline and Hour 4 of exposure]
- Change from baseline in gustation [Time frame: Baseline and Hour 4 of exposure]
Eligibility criteria
Inclusion criteria
- English or French speaking
- Ability to provide informed consent
Exclusion criteria
- History or evidence of chronic disease
- Current use of hypolipemic medication
- Current use of hormonal contraceptives
- Current use of antidepressants
- Current use of anticoagulants
- Ongoing smoking status
- Experiencing pregnancy, puerperium, or irregular menstrual cycles
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Canada · 1 center
- Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Scien — Ottawa
Identifiers
NCT: NCT06912230 · H-06-18-837