Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Lidocaine, Diphenhydramine.
- Who it may be relevant to
- Registry conditions: Laceration of Skin. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.
Interventions
- Drug Lidocaine
Lidocaine local infiltration - Drug Diphenhydramine
Diphenhydramine local infiltration
Primary outcome measures
- Sensation reduction [Time frame: Measurements will be recorded before drug injection and immediately after laceration repair.]
Secondary outcome measures (2)
- Anesthesia satisfaction by patient [Time frame: Immediately after laceration repair]
- Anesthesia satisfaction by physician [Time frame: Immediately after laceration repair]
Eligibility criteria
Inclusion criteria
- Lacerations requiring one layer of sutures
- Lacerations appropriate for repair by emergency physicians
Exclusion criteria
- Active bleeding from laceration
- Complex lacerations requiring multiple layers
- Lacerations to be repaired by a specialist service
- Patients with allergies to either diphenhydramine or lidocaine
- Laceration repairs would benefit from the use of epinephrine as an additive to the local anesthetic
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Bethesda Hospital East — Boynton Beach
Identifiers
NCT: NCT06910241 · 2195722