Recruiting NCT06908538
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: cryoablation.
- Who it may be relevant to
- Registry conditions: Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain (VANISH)
Overview
The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.
Interventions
- Device cryoablation
Cryoanalgesia, also known as Cryoablation, Cryoneurolysis, or Cryonerve Block, has been used for decades to treat chronic pain and has recently been employed for the management of Phantom Limb Pain. Cryoanalgesia involves the use of a probe to apply extreme cold (approximately -70◦C) to induce reversible axonal injury and Wallerian degeneration to produce a temporary conduction block that is sustained until regeneration of the axon and sensation is restored, typically weeks to months later.
Primary outcome measures
- Primary Outcome Measure [Time frame: 30 days]
Eligibility criteria
Inclusion criteria
- Patients who have or will have an amputation procedure;
- Patients who are willing and capable of providing informed consent;
- Patients whose age is 18 years or above, or of legal age to give informed consent specific to state and national law.
Exclusion criteria
- Women of childbearing potential who are, or plan to become, pregnant during the time of the study;
- Other medical, social, or psychological conditions that in the opinion of the Investigator precludes the subject from appropriate consent or adherence to the protocol.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 5 centers
- Berkshire Medical Center — Pittsfield
- Elliot Hospital — Manchester
- NYU Langone Health — New York
- Ohio State University — Columbus
- Medical College of Wisconsin/Froedtert Hospital — Milwaukee
Identifiers
NCT: NCT06908538 · RP-2025-0001