Comparison of Sevoflurane and Propofol on ANI
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: propofol, Sevoflurane.
- Who it may be relevant to
- Registry conditions: Propofol, Sevoflurane, Analgesia Nociception Index. Basic parameters: from 19 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparison of Sevoflurane and Propofol on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study
Overview
The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.
Detailed description
Patients will be allocated to either propofol or sevoflurane group. Nociceptive event will be defined as long-lasting tetanic stimulation, square-wave, duration of 30 seconds , amplitude of 50mA, frequency of 50 Hz. analgesia nociception index value and hemodynamic parameters will be recorded 1-minute before and after nociceptive event.
Interventions
- Drug propofol
propofol anesthesia - Drug Sevoflurane
sevoflurane anesthesia
Primary outcome measures
- analgesia nociception index change [Time frame: During anesthesia period]
Secondary outcome measures (2)
- Hemodynamic change [Time frame: During anesthesia period]
- Hemodynamic change [Time frame: During anesthesia period]
Eligibility criteria
Inclusion criteria
- American society of anesthesiologists physical status class I or II
Exclusion criteria
- history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc.
- history of allergic reaction to sevoflurane and/or propofol
- history of and/or family history of malignant hyperthermia
- neurodegenerative disorder
- psychiatric disorder
- arrhythmia
- diabetes mellitus
- drug abuse history
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06907823 · 11-2025-003