Study of Lipid Mediators in Chronic Postoperative Pain - LICP
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Blood sample + questionnaire.
- Who it may be relevant to
- Registry conditions: Breast Cancer Female, Postoperative Pain. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Belgium
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Study of Lipid Mediators in Chronic Postoperative Pain Following Breast Cancer Surgery
Overview
This interventional prospective study aims firstly to investigate variations in lipid levels in blood samples and their potential relationship with the duration and/or intensity of post-operative pain. Secondly, it aims to investigate the activation of peripheral blood mononuclear cells and neutrophils in patient blood samples. The study will enrol women aged 18 years or older who have been newly diagnosed with primary invasive or non-invasive breast cancer requiring surgical removal of the tumour, with or without axillary surgery. The main objectives of the study are To assess whether there is an association between circulating levels of lipid mediators and chronicity (\> 3 months) of postoperative pain after breast cancer surgery. To assess whether circulating levels of lipid mediators can predict chronicity of postoperative pain in breast cancer surgery. To assess the existence of an association between resected tissue levels of lipid mediators and chronicity of postoperative pain in breast cancer surgery. To assess whether tissue levels of lipid mediators can predict chronicity of postoperative pain in breast cancer surgery.
Interventions
- Other Blood sample + questionnaire
* blood sample before tumor surgery and at every follow-up visit * questionnaire before tumor surgery and at every follow-up visit
Primary outcome measures
- Pain intensity [Time frame: Throughout the study, an average of 2 years]
- Pain duration [Time frame: Throughout the study, an average of 2 years]
- Lipid Mediator Levels in Blood [Time frame: Throughout the study, an average of 2 years]
Eligibility criteria
Inclusion criteria
- Women older than 18 years
- Newly diagnosed primary invasive or non-invasive breast cancer, requiring surgical excision of the tumor, with or without axillary surgery
- Able to give informed consent
Exclusion criteria
- Men
- Women aged less than 18 years
- Pregnant women
- History of major psychiatric disorders
- Previous breast or axillary surgery, recurrent disease or detectable metastatic disease at the time of diagnosis
- Unable to give informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Screening
Study locations
Belgium · 1 center
- Cliniques universitaires Saint-Luc (UCLouvain) — Brussels
Identifiers
NCT: NCT06907810 · LICP