Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions..
- Who it may be relevant to
- Registry conditions: Gait Disorders, Neurologic, Atypical Parkinson Disease, fNIRS, Aging. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Walking and Thinking - Brain Activity During Complex Walking in Atypical Parkinsonian Syndromes
Overview
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as atypical Parkinson's disease (APD) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecologically valid state. The investigators aim therefore to explore brain function during complex walking in healthy and APD by investigating the effects of age and neurological disease on motor-cognitive performance and its neural correlates during three conditions of complex walking (dual-task walking, navigation and a combination of both) using non-invasive measures of brain activity (functional near infrared spectrometry, fNIRS) and advanced gait analysis in real time in older healthy adults and people with APD.
Interventions
- Other Assessment of brain activity with fNIRS and behavioural assessments (motor, motor-cognitive and cognitive) during three complex walking conditions.
Dual-task walking with the auditory stroop task. Navigational walking - a course consisting of a distribution of 45 and 90 degrees turns to the left and right Navigational and dual-task walking (condition 1 and 2 together)
Primary outcome measures
- Functional near infrared spectrometry (fNIRS) [Time frame: Baseline]
- Gait performance during all conditions [Time frame: Baseline]
- Dual-task performance-reaction time [Time frame: Baseline]
Secondary outcome measures (12)
- Resting-state functional near infrared spectrometry (rsfNIRS) [Time frame: Baseline]
- Cognitive function- composite score [Time frame: Baseline]
- Cognitive function - verbal fluency [Time frame: Baseline]
- Cognitive function - Attention and psychomotor processing speed [Time frame: Baseline]
- Cognitive function - Episodic memory [Time frame: Baseline]
- Cognitive function - Inhibition & task-set switching [Time frame: Baseline]
- Self-reported level of physical activity [Time frame: Baseline]
- Physical activity [Time frame: Baseline]
- Motor function/disease severity [Time frame: Baseline]
- Balance performance [Time frame: Baseline]
- Anxiety and depression [Time frame: Baseline]
- Walking ability [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- clinical diagnosis of PSP according to Movement Disorder Society (MDS) (2017) or
- MSA according to MDS criteria (2022)
- the ability to walk with or without a mobility device for ≤5 minutes continuously
Exclusion criteria
- cognitive difficulties affecting the ability to understand and/or follow verbal/written - instructions
- severe freezing of gait
- Severe hearing or visual impairments that affect participation in the assessments
- Other neurological diseases
- Other diseases that can affect gait or balance.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Sweden · 1 center
- Karolinska Institutet — Solna
Identifiers
NCT: NCT06906276 · 4-2452/2024 · 2020-03059