Thick Cornea with High Back Elevation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: pentacam.
- Who it may be relevant to
- Registry conditions: Corneal Thickness Measurement. Basic parameters: from 6 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Long Term Follow-up Study on Thick Cornea with High Back Elevation
Overview
To follow up cases of thick cornea with high back elevation by pentacam.
Detailed description
The cornea plays a crucial role in refraction and so help in good visual acuity. with its thickness and back elevation being essential parameters in diagnosing and managing corneal diseases such as keratoconus.
The normal human cornea has a central thickness of approximately 540-550 µm. The periphery is generally thicker, reaching up to 700 µm. Corneal thickness is influenced by genetics, hydration, and intraocular pressure.Thick Cornea (\> 540 µm): Seen in conditions such as corneal edema and Fuchs' dystrophy. Thin Cornea (\< 500 µm): Observed in keratoconus, LASIK-induced thinning, and corneal ectasia.
Back corneal elevation is assessed using corneal topography or tomography, typically referenced to a best-fit sphere (BFS). In normal cases, Back corneal elevation is usually ≤12 µm above the BFS, indicating a structurally healthy cornea without signs of ectasia. Susceptible elevation ranges between 12-20 µm, which may be an early indicator of corneal instability, such as subclinical keratoconus. Therefore, it should be evaluated alongside other parameters, including pachymetry, anterior curvature, and biomechanical properties. Abnormal back corneal elevation is generally considered \>20 µm, particularly if localized or asymmetric, and is strongly associated with corneal ectatic disorders such as keratoconus, pellucid marginal degeneration, or post-LASIK ectasia. This abnormal elevation is often accompanied by other risk factors, including increased posterior corneal curvature, corneal thinning, and significant asymmetry, necessitating further assessment and monitoring.
Many cases of thick cornea are associated with high back elevation and this discourage refractive surgery in such cases so in investigator's study the investigator will follow up these cases to determine if these corneas are considered normal corneas or not.
Interventions
- Device pentacam
we will follow up on cases of thick cornea with high back elevation
Primary outcome measures
- Measurement of corneal thickness and back corneal elevation by pentacam device [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
Any patient can interact with pentacam. Both Genders: include both males and females. Patients with thick cornea (>540 µm) with high back elevation.
Exclusion criteria
- Patients with any eye disease (significant cataract or unstable glaucoma)
- Uncontrolled external disease such as blepharitis , moderate to severe dry eye and allergy.
- Patient with ocular disease such as uveitis, post herpetic infection and corneal opacity
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06905977 · Thick cornea