PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Transient Global Amnesia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. A recent study on a small sample size (N=29) highlighted an association between obstructive sleep apnea syndrome and amnesic stroke. Our study seeks to confirm or refute these results on a larger cohort (N=200-250). A better understanding of the pathophysiological processes involved would open up new therapeutic avenues.
Primary outcome measures
- To assess the prevalence of obstructive sleep apnea syndrome in patients who have experienced an amnestic stroke. [Time frame: Within the last 2 years]
Eligibility criteria
Inclusion criteria
- Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria:
- The stroke must have been documented and reported by a competent witness present during the stroke.
- Anterograde amnesia during the stroke.
- Absence of vigilance, personality, and cognitive disorders other than memory disorders (aphasia, apraxia, etc.).
- Absence of focal neurological symptoms during the episode and its aftermath.
- Absence of epileptic manifestations.
- Resolution of the episode in less than 24 hours.
- Exclusion of patients with a history of recent head trauma or active epilepsy (undergoing regular treatment or having experienced a seizure in the last 2 years).
- Subjects who have not expressed opposition to the reuse of their data for scientific research purposes.
Exclusion criteria
- Patients who have expressed opposition to the retrospective reuse of their data for scientific research purposes.
- Patients with active epilepsy
- Patients with recent head trauma
- Patients with an MMS < or equal to 25
- Subject under guardianship or curatorship
- Subject under judicial protection
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- Service de Neurologie - CHU de Strasbourg - France — Strasbourg
Identifiers
NCT: NCT06903026 · 8781