Not yet recruiting NCT06900192
A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Orca-Q, myeloablative regimen.
- Who it may be relevant to
- Registry conditions: Primary Progressive Multiple Sclerosis, Multiple Sclerosis, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Multicenter Phase 1 Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis Using Orca-Q, an Engineered Donor Graft Derived From Mobilized Peripheral Blood
Overview
A study of alloHCT with Orca-Q for the treatment of primary progressive multiple sclerosis (MS).
Detailed description
This study will evaluate alloHCT with Orca-Q, an allogeneic hematopoietic graft isolated from a donor's hematopoietic cells for the treatment of primary progressive MS.
Interventions
- Biological Orca-Q
Allogeneic (donor) stem cell graft - Drug myeloablative regimen
Myeloablative regimen of busulfan, fludarabine, and thiotepa.
Primary outcome measures
- Severe acute Graft-versus-Host-Disease-free survival [Time frame: 365 days after infusion]
Secondary outcome measures (2)
- Evaluate treatment response [Time frame: Measurements will be taken at 9 and 12 months after infusion]
- Evaluate safety of treatment [Time frame: Measured from time of enrollment to end of study participation (from date of consent to month 12).]
Eligibility criteria
Inclusion Criteria (Recipient):
- Participants aged ≥18 and ≤65 years with primary progressive multiple sclerosis
- A diagnosis of PPMS by 2017 McDonald criteria and 2013 clinical course revision102
- CSF with elevated IgG index or 2 or more oligoclonal bands
- EDSS (see Appendix 9) between 2.0 and 5.5 inclusive
- Based on review of the clinical records, there must be a deterioration in the EDSS of at least 1 or more points over the previous 4 years (or less).
- Eligibility criteria confirmed by the Eligibility Review Group (Appendix 10)
- Recipients who have been treated with ocrelizumab, rituximab, ofatumumab, ublituximab, or alemtuzumab must undergo a washout period as described in Appendix 14 prior to their planned day 0.
- Recipients must be willing to undergo mobilized autologous peripheral blood stem cell collection to create a cryopreserved rescue product prior to alloHCT.
- Ability to undergo MRI without general anesthesia
- Ability to undergo all tests and procedures in the study
- Patients who are not vaccinated for COVID-19 must have no symptoms of COVID-19 and have negative testing for COVID-19. For other vaccine-preventable illnesses, it is recommended that patients are current on their vaccination schedule.
Exclusion criteria
- History of Progressive Multifocal Leukoencephalopathy
- Organ dysfunction or disease that would jeopardize survival after hematopoietic cell transplantation, including but not limited to the following:
- Renal insufficiency as defined by an estimated GFR <60 mL/minute
- Cardiac dysfunction as defined by symptomatic coronary artery disease, congestive heart failure, valvular heart disease, cardiomyopathy, uncontrolled arrhythmia(s), or left ventricular ejection fraction <50%. Participants with a history of these conditions may enroll if they are demonstrated to have optimal cardiac function (as defined by echocardiography or multi-gated acquisition scan)
- Pulmonary dysfunction that poses a risk of mortality after transplant, defined as pre-transplant pulmonary function testing demonstrating a FEV1 <70% expected and/or a DLCOadj <70% expected.
- Necroinflammatory or fibrotic liver disease with evidence of liver dysfunction, including but not limited to jaundice, hepatic encephalopathy, or portal hypertension
- Marrow dysfunction that poses a risk of peri-transplant mortality, defined as an absolute neutrophil count (<1000/mm3) below the lower limit of normal, or a platelet count below 50,000/mm3.
- Poorly controlled hypertension despite appropriate therapy, defined as a diastolic blood pressure greater than 90 mm Hg while on therapy.
- Poorly controlled diabetes mellitus, defined as HgbA1c ≥ 6.5% despite therapy or recurrent hypoglycemia while on therapy.
- Extreme protein-calorie malnutrition defined by Body Mass Index <18 and unintentional weight loss (3 kg in the last month or 6 kg in the last 6 months.)
- History of smoking either tobacco or other herbal products in the last 3 months.
- Planned pharmaceutical in vivo or ex vivo T cell depletion (TCD), eg, cladribine, or peritransplant antithymocyte globulin (ATG). For participants who have previously been exposed to a TCD agent, a 5-half-life washout of the agent must occur prior to planned day 0 (day 0 is defined as the day of infusion Orca-Q Prime). The washout period for alemtuzumab is listed in Appendix 14.
- HIV seropositive.
- HBV serology results indicating chronic HBV infection per https://www.cdc.gov/hepatitis/hbv/interpretationOfHepBSerologicResults.htm, unless HBV PCR negative. HBV seropositive participants should be on antiviral therapy after transplant.
- HCV seropositive, unless PCR negative and having undergone 'curative' antiviral therapy.
- Participant has active uncontrolled infection
- Participant has demonstrated lack of compliance with prior medical care
- Participants with known active malignancy. It is recommended that patients are current on cancer screening tests for their age and family history as per the NCCN \[The National Comprehensive Cancer Network®\] Guidelines. Screening should be performed, if indicated, per NCCN guidelines prior to study treatment.
- Participants whose life expectancy is severely limited by illness other than multiple sclerosis
- Females who are pregnant or breast feeding.
- Medical or psychiatric conditions that compromise ability to give informed consent or to comply with treatment protocol
- Inability to undergo an MRI scan
- Currently receiving treatment with investigational agents
- Positive for JC virus DNA in the CSF or blood during screening.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Sequential
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06900192 · 75412