Prognosis and Risk Factors for Acute Kidney Injury
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Acute Kidney Injury. Basic parameters: from 20 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Korea
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Analysis for Prognosis and Risk Factors for Acute Kidney Injury: Multi-center Cohort Study
Overview
The aim of our study is to analyze the accurate diagnosis and prognosis of acute kidney injury (AKI) based on its severity and to define long-term clinical and socioeconomic outcomes. Investigators defined the AKI group among adults aged 20 years or older who visited enrolled center and underwent at least two blood tests, including serum creatinine, within an interval of 7 days or less and a control group was matched 1:1 to the AKI group based on age, sex, year of visit, and baseline kidney function, forming the study population. Investigators then collected and analyzed various clinical, laboratory, and hospitalization records including demographic data, anthropometric data, laboratory data, and medical history.
Primary outcome measures
- Change from Baseline in Serum Creatinine [Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date]
Secondary outcome measures (4)
- Change from Baseline in Urine Protein/Creatinine Ratio [Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date]
- Incidence of Receiving Renal Replacement Therapy [Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date]
- Change from Baseline in Serum Hemogloblin Level [Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date]
- Change from Baseline in Serum Albumin Level [Time frame: From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date]
Eligibility criteria
Inclusion criteria
- Adults over 20 years old who visited Parcitipating Medical Center (Seoul National University Hospital, Bundang Seoul National University Hospital, SMG-SNU Boramae Medical Center, Keimyung University Dongsan Medical Center) between 2006 and 2021
- The AKI group is defined as individuals meeting the AKI diagnostic criteria of the KDIGO Guideline (an increase in serum creatinine of ≥0.3 mg/dL or ≥1.5 times the baseline level) is enrolled.
- The Control Group is defined as individuals from the study population who do not meet the AKI criteria and are matched 1:1 based on age, sex, year of visit, and baseline renal function.
Exclusion criteria
- Individuals under 20 years old
- Individuals who did not undergo serum creatinine tests meeting the criteria
- Individuals with pre-existing end-stage kidney disease (ESKD) who have undergone dialysis or kidney transplantation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
South Korea · 1 center
- Seoul National University Hospital — Seoul
Identifiers
NCT: NCT06898944 · H-2208-015-1347