Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Permethrin Cream, 5%, Permethrin Cream, 5%, Ivermectin 200 µg/kg.
- Who it may be relevant to
- Registry conditions: Scabies. Basic parameters: 6 years — 15 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Pakistan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparison of Topical Permethrin 1 Day Verses 2 Day Application Versus Oral Ivermectin for Treatment of Scabies in Children Greater Than 6 Yrs of Age
Overview
Scabies is highly contagious,pruritic infestation of skin.Various treatment modalities have been used but search for ideal scabicide is ongoing.we wnt to coduct this study to compare the outcome of permethrin verses ivermectin in children for treatment of scabies .This randomized clinical trial will be done in children hospital lahore for 12 months.Sample size of 90 cases;30 in each group will be included through non probability consecutive sampling.Then patient will be randomly divided into 3 groups.In group A patient will be given 5% permethrin topical application to whole body single application. In Group B ,patients will be given topical permethrin for twice application 24 hrs appart ,In group C patients will be given Tablet Ivermectin single dose 200microgram/kg.Then patients will be examined after 2 weeks and 4 weeks for no of lesions and pruritis and cure will be labeled.All this information will be recorded on performa .Data will be entered and analysed by using SPSS version 26.Three groups will be compared for cure by using chi-square test.P value less than and equal to 0.05 will be considered as significant.
Interventions
- Drug Permethrin Cream, 5%
Permethrin 5% cream will be given as a single application - Drug Permethrin Cream, 5%
Permethrin Cream will be given as twice application - Drug Ivermectin 200 µg/kg
Group C will be given Tab Ivermectin
Primary outcome measures
- Cure of scabies. [Time frame: 12 months]
Eligibility criteria
Inclusion criteria
- Age 6-15
- Both genders
- Diagnosed with scabies (as per operational definition)
Exclusion criteria
- Children with recurrent scabies on medical record
- Known allergy to ivermectin or permethrin.
- Widespread eczema or impetigo.
- Liver dysfunction or renal failure
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Pakistan · 1 center
- Children Hospital Lahore — Lahore
Identifiers
NCT: NCT06896929 · 715-24-10-2023ApprovedbyCHUCHS