Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Dexamethasone, Placebo.
- Who it may be relevant to
- Registry conditions: Post Operative Pain Control, Endodontic Treatment. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect of Intentional Extrusion of an Intracanal Corticosteroid Solution on Post Endodontic Treatment Pain: a Randomized Clinical Trial
Overview
The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis (SIP/SAP). The main question it aims to answer: Is there an analgesic effect of extruding an intracanal solution of DXA into the periapical tissues in patients diagnosed with SIP/SAP? Researchers will compare dexamethasone to a placebo to see if the extrusion dexamethasone works in reducing post-endodontic treatment pain.
Interventions
- Drug Dexamethasone
a 2 ml solution of dexamethasone (3.3mg/ml) will be flushed in the root canal and intentionally extruded to the periradicular tissues to assess its potnetial sedative effect - Other Placebo
2ml of normal saline will be used as placebo to be flushed and extruded through the canals to the periradicular tissues
Primary outcome measures
- Post-operative pain following root canal treatment [Time frame: at 12, 24, 48 and 72 hours after completing the treatment]
Eligibility criteria
Inclusion criteria
- A diagnosis of irreversible pulpits with symptomatic apical periodontitis
- Adult patients (aged 18 - 70)
- Healthy patients or those with a well-controlled disease (ASA I \& II)
Exclusion criteria
- A diagnosis of necrotic pulp, or normal apical tissues
- Patients with a severe systemic disease (ASA III or higher)
- Patients who received analgesics12 hours before presentation
- Previously treated/initiated Endodontics treatment on the same tooth
- Unopposed teeth
- Third molar teeth
- Non-restorable teeth
- Periodontally compromised teeth
- Pregnant or lactating patients
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06894069 · 10/2023/ 32001