PHArmacotherapy Assessed Using Neuroprobing With TransOsseal Magnetic Stimulation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: TMS-EEG.
- Who it may be relevant to
- Registry conditions: Epilepsy. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this observational study is to investigate how prescribed anti-seizure medications (ASMs) affect cortical excitability in adults with epilepsy. The main questions it aims to answer are: 1. Does the magnitude of transcranial magnetic stimulation (TMS)-evoked potentials (TEPs) measured with electroencephalography (EEG) change between OFF and ON medication states? 2. Do these changes in TEP amplitude persist over time? Researchers will compare each participant's measurements in the OFF state with those in the ON state to see if TEPs change following ASM (re)start. Participants will undergo one TMS-EEG session scheduled around their prescribed ASM (re)start and one 1-6 months later.
Interventions
- Other TMS-EEG
Evoked brain activity is measured with the help of TMS-EEG in epilepsy patients OFF and ON medication.
Primary outcome measures
- Change in TEP magnitude [Time frame: 1 day]
Secondary outcome measures (1)
- Persistence of TEP changes over time. [Time frame: 1-6 months]
Eligibility criteria
Inclusion criteria
- Adult patients (≥ 18j) with epilepsy receiving a prescription for an anti-seizure medication for clinical reasons
- Written informed consent
Exclusion criteria
- Presence of any electrical implants (e.g. neurostimulator or drug delivery system) or any metallic implants anywhere in the head (excluding teeth)
- Increased intracranial pressure
- Uncontrolled psychiatric disorder
- Use of any kind of drug or alcohol, nicotine allowed
- For female participants: If pregnancy cannot be ruled out with sufficient certainty, a pregnancy test (urine) will be carried out before using TMS
- Inability to give consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Switzerland · 1 center
- University Hospital Bern — Bern
Identifiers
NCT: NCT06892457 · 5958