The Immediate Effect of Applying Transcutaneous Electrical Nerve Stimulation (TENS) on Sympathetic Ganglion and Gastrocnemius for Popliteal Blood Flow
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Transcutaneous Electrical Nerve Stimulation，TENS.
- Who it may be relevant to
- Registry conditions: Transcutaneous Electrical Nerve Stimulation (TENS), Popliteal, Blood Flow, Sympathetic Ganglia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This study aims to evaluate the immediate hemodynamic effects of transcutaneous electrical nerve stimulation (TENS) on the popliteal artery and vein. Vascular issues like PAOD and DVT are common in patients with diabetes, obesity, or immobility due to increased resistance and reduced blood flow. Traditional treatments (medication or surgery) are not always feasible, prompting interest in TENS as an alternative. Although primarily used for pain relief, TENS may enhance blood flow. This research compares different stimulation frequencies (80 Hz vs. 4 Hz) and sites (gastrocnemius muscle vs. thoracolumbar sympathetic ganglia) to identify the most effective configuration.
Interventions
- Device Transcutaneous Electrical Nerve Stimulation，TENS
low frequency (4Hz) and sympathetic ganglion(T12.L1.L2) low frequency (4Hz) and gastrocnemius high frequency (80Hz) and sympathetic ganglion(T12.L1.L2) high frequency (80Hz) and gastrocnemius
Primary outcome measures
- Doppler ultrasound measurement of changes in popliteal fossa blood flow [Time frame: 45 minutes]
Secondary outcome measures (1)
- heart rate [Time frame: 45 minutes]
Eligibility criteria
Inclusion criteria
- Healthy people
- Age: 18 years and above (inclusive)
- Body mass index (BMI) between 18.5 and 24
Exclusion criteria
- Unable to complete two interventions within a week
- Have contraindications to electrotherapy (for example: metal implants in the body, open wounds, pregnancy, sensory loss)
- Obvious varicose veins 4. Unable to lie down for about 1 to 2 hours 5. Taking drugs or nutritional supplements that affect autonomic nervous activity or vasodilation (for example: Ginkgo biloba) 6. Smoking 7. Ankle and Ankle Index (ABI) less than 0.9 or greater than 1.3
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Taiwan · 1 center
- Kaohsiung Medical University — Kaohsiung City
Identifiers
NCT: NCT06882733 · KMUHIRB-E(I)-20240357