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Not yet recruiting NCT06876870

MR-Evaluation of Renal Function in Anesthetized Pediatric Patients

Phase IV Interventional Renal Blood Flow Anesthesia MRI Renal Oxygenation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Anesthesia Maintenance Agent.
Who it may be relevant to
Registry conditions: Renal Blood Flow, Anesthesia, MRI, Renal Oxygenation. Basic parameters: 1 months — 14 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Overview

The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys. Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis. In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.

Detailed description

See the study protocol

Interventions

  • Drug Anesthesia Maintenance Agent
    Difference in renal blood flow (RBF) between Propofol and Sevoflurane groups. Quantified by specific Multiparametric MRI metrics (e.g., (Renal blood flow by phase contrast imaging) (regional perfusion by Arterial Spin labeling (ASL) and global and regional oxygenation by Blood oxygen dependent signal (BOLD))

Primary outcome measures

  • Differences in RBF, as measured by phase contrast imaging with mpMRI, between propofol and sevoflurane anesthesia. [Time frame: The extra imaging is expected to take 20-30 minutes.]
Secondary outcome measures (4)
  • Differences in regional renal tissue perfusion, as measured by arterial spin labelling (ASL) with mpMRI, between propofol and sevoflurane anaesthesia [Time frame: The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images]
  • Differences in regional and global renal oxygenation, as measured by Blood Oxygen Level Dependent (BOLD) signal via mpMRI, between propofol and sevoflurane anaesthesia. [Time frame: The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images]
  • The difference in relation of RBF to systemic non-invasive blood pressure, between propofol and sevoflurane anaesthesia [Time frame: The entire MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images]
  • The difference plasma renin concentration, measured by a blood sample, between propofol and sevoflurane anaesthesia [Time frame: 1 minute]

Eligibility criteria

Inclusion criteria

  • Pediatric Patients (1 month -14 years of age)
  • Indicated for MRI with anesthesia
  • ASA (American Society of Anesthesiologists) physical status I-III

Exclusion criteria

  • Known renal impairment or chronic kidney disease
  • Severe cardiac or pulmonary disease
  • Allergy to either Propofol or Sevoflurane
  • Contraindications to Magnetic Resonance Imaging
  • Contraindications to either Propofol or Sevoflurane
  • Declined participation or declined consent from patients, parents or guardians
  • Ongoing acute kidney injury

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Basic science

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT06876870 · MERAPED · 2025-520627-25-00

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗