Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Prescribed Medications, Deep brain stimulation adjustment.
- Who it may be relevant to
- Registry conditions: Movement Disorders. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.
Interventions
- Other Prescribed Medications
participant's movement disorders medications, prescribed by their treating physician - Other Deep brain stimulation adjustment
Deep brain stimulator parameters may be adjusted within normal clinical limits
Primary outcome measures
- Neural signal biomarkers [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- Patients 18 years of age and above
- Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders:
- Parkinson's disease
- Dystonia
- Tremor, including essential tremor
- Cerebellar ataxia
- Other hyperkinetic movement disorders, such as chorea and tics
Exclusion criteria
\- Patients with dementia
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Pennsylvania Hospital — Philadelphia
Identifiers
NCT: NCT06848530 · 857558