Unbound Cloxacillin Concentrations During Continuous Infusion
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Unbound cloxacillin concentration.
- Who it may be relevant to
- Registry conditions: Staphylococcal Infections. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Concentration of Unbound Cloxacillin in Adults Treated With Continuous Infusion Via Elastomeric Pump
Overview
Cloxacillin is the first-line choice for the treatment of severe infections caused by the bacterium Staphylococcus aureus in Sweden. Over the past year, cloxacillin is increasingly administred through continuous infusion. In this study, the free (unbound) concentration of cloxacillin when administered as a continuous infusion will be measured to ensure that the free concentration is neither too high nor too low. A PK/PD model will be developed to predict which dosage of cloxacillin is appropriate for an individual based on age, gender, kidney function, and serum-protein level.
Interventions
- Diagnostic test Unbound cloxacillin concentration
Unbound cloxacillin concentration measured at baseline, after 4h, after 24h and after 48h of continuous infusion.
Primary outcome measures
- Free (unbound) cloxacillin concentration [Time frame: From enrollment to end of follow up at 48 hours]
Eligibility criteria
Inclusion criteria
- Age 18 years or older
- Treating physician has decided to start continuous infusion of cloxacillin
Exclusion criteria
- Unwilling or unable to provide written informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
Sweden · 1 center
- Västmanlands sjukhus Västerås — Västerås
Identifiers
NCT: NCT06848387 · 992496/KLONC