Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: transvaginal Ultrasound.
- Who it may be relevant to
- Registry conditions: OVARIAN STIMULATION. Basic parameters: 18 years — 48 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Arab Emirates
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles. Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.
Interventions
- Other transvaginal Ultrasound
The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre Oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time.
Primary outcome measures
- the investigators will see the corellation between the follicular volume at the time of trigger with the oocyte maturity in patients with less than four follicles of a follicle size of at least 11 mm . [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- Reproductive age group: 18 -48
- undergoing ovarian stimulation for oocyte vetrification
- undergoing IVF/ ICSI with PGT-A / PGT-M / PGT- Sr
- less than or equal to 3 AFC on initiation of stimulation
- follicular phase stimulation
Exclusion criteria
- surgically retrieved sperm
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-only
Study locations
United Arab Emirates · 1 center
- ART Fertility Clinics — Abu Dhabi
Identifiers
NCT: NCT06839274 · 2408-ABU-013-AS