Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Rectus sheath block, Intrathecal morphine.
- Who it may be relevant to
- Registry conditions: Ultrasound, Rectus Sheath Block, Intrathecal Morphine, Postoperative Analgesia. Basic parameters: 18 years — 65 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy: A Randomized Trial
Overview
This study aims to compare the effectiveness and safety of ultrasound-guided rectus sheath block versus intrathecal morphine for postoperative analgesia in patients undergoing open total abdominal hysterectomy.
Detailed description
Effective postoperative analgesia is crucial for enhancing recovery and patient satisfaction following major surgical procedures, such as total abdominal hysterectomy (TAH).
Rectus sheath block (RSB), an ultrasound-guided regional anesthesia technique, involves the injection of local anesthetic into the rectus sheath, providing analgesia to the anterior abdominal wall. RSB is used to block the sensory nerves of the anterior abdominal wall and thereby contributing to pain relief after lower abdominal surgeries.
Intrathecal morphine (ITM) provides a highly effective method of analgesia by delivering the medication directly into the cerebrospinal fluid (CSF).
Interventions
- Drug Rectus sheath block
Patients will receive rectus sheath block (20 ml bilaterally, bupivacaine 0.25%) after induction of general anesthesia. - Drug Intrathecal morphine
Patients will receive 150 µg intrathecal morphine after induction of general anesthesia.
Primary outcome measures
- Total morphine consumption [Time frame: 24 hours postoperatively]
Secondary outcome measures (6)
- Time to the first request for the rescue analgesia [Time frame: 24 hours postoperatively]
- Degree of pain [Time frame: 24 hours postoperatively]
- Degree of sedation [Time frame: Intraoperatively]
- Degree of patient satisfaction [Time frame: 24 hours postoperatively]
- Time of hospital discharge [Time frame: 28 days postoperatively]
- Incidence of adverse events [Time frame: 24 hours postoperatively]
Eligibility criteria
Inclusion criteria
- Age: 18 - 65 years old.
- American Society of Anesthesiologists (ASA) physical status (I -II).
- Patients undergoing open total abdominal hysterectomy.
Exclusion criteria
- Hepatic, renal, or cardiac disease.
- Any known allergy to local anesthetic.
- Physical or mental conditions which may vague measuring postoperative pain following surgery.
- History of chronic use of analgesic as nonsteroidal anti-inflammatory drugs (NSAIDs) or central nervous system (CNS) depressants as antiepileptic, and bleeding disorders.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Ain Shams University — Cairo
Identifiers
NCT: NCT06837506 · FMASU R03/2024/2025