Atrial Strain in Septic Shock
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Septic Shock, Left Atrial Strain, Right Atrial Strain, Transthoracic Echocardiography. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Assessment of Left And Right Atrial Strain in Septic Shock
Overview
Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.
Primary outcome measures
- variation of LASr between ECOPAC and UWS [Time frame: 1 year]
Secondary outcome measures (12)
- variation of LAScd between ECHOPAC and UWS [Time frame: 1 year]
- variation of LASct between ECHOPAC and UWS [Time frame: 1 year]
- Comparison of LASr measurements in apical 2-chamber views [Time frame: 1 year]
- Comparison of LAScd measurements in apical 2-chamber views [Time frame: 1 year]
- Comparison of LASct measurements in apical 2-chamber views [Time frame: 1 year]
- Comparison of right atrial strain RASr between ECHOPAC and UWS [Time frame: 1 year]
- Comparison of right atrial strain RAScd between ECHOPAC and UWS [Time frame: 1 year]
- Comparison of right atrial strain RASct between ECHOPAC and UWS [Time frame: 1 year]
- Comparison of LAS in AutoStrain versus manual mode [Time frame: 1 year]
- Comparison of RAS in AutoStrain versus manual mode [Time frame: 1 year]
- Comparison of LAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC [Time frame: 1 year]
- Comparison of RAS measurements in AutoStrain (UWS) versus manual mode on ECHOPAC [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- Age: >18 years
- Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)
- TTE performed as part of medical management
- No objection to data usage
Exclusion criteria
- Pregnancy
- Moderate to severe valvular regurgitation/stenosis (>grade 2)
- Ventricular or supraventricular tachyarrhythmia (HR >140 bpm) at the time of TTE
- Poor echogenicity preventing LAS measurement
- Mechanical circulatory support
- Pacemaker dependence
- Patients under guardianship
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- CHRU Amiens — Salouël
Identifiers
NCT: NCT06832436 · PI2025_843_0034