The ROAR Study: Reactive Oxygen Species and Reproduction
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Oxidative stress markers.
- Who it may be relevant to
- Registry conditions: Ovarian Aging, IVF Outcome, Oxidative Stress. Basic parameters: 18 years — 43 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.
Interventions
- Diagnostic test Oxidative stress markers
We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes
Primary outcome measures
- Implantation rate [Time frame: From enrollment to transfer of all embryos - can be anywhere from 8 weeks to 1 year (or sometimes longer if pregnancy is achieved)]
Eligibility criteria
Inclusion criteria
- Female age 18-43 years
- Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
- Male partners 18 years of age or older.
- Must be a registered patient at UCSF Center for Reproductive Health
- Patient and partner must both be physically present on the day of retreival
Exclusion criteria
- Female partner age 44 or older
- Planning fresh transfer (hybrid PGS cycle)
- Cleavage stage biopsy
- Planning to use frozen sperm
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- University of California, San Francisco — San Francisco
Identifiers
NCT: NCT06831019 · 24-42357