Can You Breathe Your Way To Better Health?
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Hight intensity interval training, Cyclic Hyperventilation with Retention.
- Who it may be relevant to
- Registry conditions: Cancer, Chronic Stress, Autonomic Dysfunction. Basic parameters: 18 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The purpose of this clinical trial is to explore the effects of either a 2-week high-intensity interval training (HIIT) or breath training intervention on measures of overall health, circulating biomarkers of stress, and immune function. Specific aims include: - Does a 2-week HIIT or breath training intervention improve measurements of overall health, including heart rate variability, physical activity, sleep quality, and severity of depression, anxiety, and stress? -Does a 2-week HIIT or breath training intervention improve circulating concentrations of stress-related biomarkers? Does a 2-week HIIT or breath training intervention improve immune function? Researchers will compare HIIT and breath training to see if equivalent immune improvements are observed. Participants will: -Undergo 2 weeks of HIIT or breath training interventions at a frequency of 3 times per week for 30 minutes or 5 times per week for 5 minutes if placed into an intervention group. -Undergo testing measures at the two pre- and post-intervention time points, if placed in the intervention groups or the healthy control group.
Interventions
- Behavioral Hight intensity interval training
Participants assigned to this intervention group will complete 6 supervised HIIT sessions over 2 weeks. - Behavioral Cyclic Hyperventilation with Retention
Participants of this intervention group will complete a total of 10 remote guided breathing sessions on Zoom over 2 weeks.
Primary outcome measures
- Serum Analysis: C-reactive protein (CRP) [Time frame: Visit 1(Week 1) and Visit 3 (Week 4): 15 minutes for blood draw. The assay itself takes 3 hours.]
- Serum Analysis: Brain Derived Neurotrophic Factor (BDNF) [Time frame: Visit 1A (Week 1) and Visit 2A (Week 4): 15 minutes for blood draw. The assay itself takes 3 hours.]
- Natural Killer cell quantity [Time frame: Visit 1(Week 1) and Visit 3 (Week 4): 15 minutes for blood draw. The assay itself takes ~10-12 hours.]
- Natural Killer Cell Cytotoxicity [Time frame: Visit 1(Week 1) and Visit 3 (Week 4): 15 minutes for blood draw. The assay itself takes ~10-12 hours.]
- Heart Rate Variability (HRV) [Time frame: Visit 2 (week 1) and Vist 4 (week 4)]
Secondary outcome measures (6)
- Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) [Time frame: Visit 1 (week 1) 10 minutes]
- Depression Anxiety and Stress Scale (DASS-21) [Time frame: Visit 1 (week 1) and Visit 3 (week 4) 10 minutes each]
- Pittsburg Sleep Quality Index (PSQI) [Time frame: Visit 1 (week 1) and Visit 3 (week 4) 10 minutes each]
- Wisconsin Upper Respiratory Symptom Survey (WURSS-21) [Time frame: Visit 1 (week 1) and Visit 3 (week 4) 10 minutes each]
- Physical Activity and Sleep Tracking [Time frame: 4 weeks]
- VO2Max [Time frame: Visit 2 (week 1) 30-45 minutes]
Eligibility criteria
Inclusion criteria
- Age, 18-50 years
- Sex, Male and Female
- Informed Consent, The capability and willingness to give written informed consent to understand the exclusion criteria and to accept the randomized group assignment is required.
- PAR-Q+, The capability and willingness to complete the physical activity readiness questionnaire, with no medical clearance needed.
- Physical Activity: Participants must refrain from regular HIIT and structured breathing practices for a month before participation
- Depression, Anxiety, and Stress Scale, Subcategory Scoring (DASS-21) Participants must score in the mild or greater category for Depression, Anxiety, and Stress. Depression ≥ 10, Anxiety ≥ 8, and Stress ≥ 14.
Exclusion criteria
- Age: Individuals under 18 years and over 50 years
- Significant Respiratory Conditions, including but not limited to asthma, chronic obstructive pulmonary disease,
- Significant Cardiovascular Disease: Participants with a known cardiovascular condition such as a previous myocardial infarction, congestive heart failure, stroke, or transient ischemic attack, cardiomyopathy, serious arrhythmia, peripheral vascular disease, untreated atherosclerosis, or hypertension.
- Significant Musculoskeletal Disease, including but not limited to osteopenia, osteoporosis, rheumatoid arthritis, and sarcopenia
- Cognitive and Mental Health, including but not limited to untreated anxiety, untreated depression, post-traumatic stress disorder, and thoughts of suicide.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Health services research
Study locations
United States · 1 center
- University of Northern Colorado, 1610 Gunter Hall, 1828 10th Ave, Greeley, CO 80631 — Greeley
Identifiers
NCT: NCT06829836 · 2404058931