Conditioning Regimen of Melphalan-busulfan and Fludarabine: a Randomized Study of Different Dose of Melphalan
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: melphalan.
- Who it may be relevant to
- Registry conditions: Toxicities, Survivorship. Basic parameters: 18 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Conditioning Regimen of Melphalan-busulfan and Fludarabine: a Randomize Study Comparing 100mg/m2 to 140mg/m2 Melphalan for Adult Patients With Acute Myeloid Leukemia or Myelodysplasia Syndrome.
Overview
Conditioning regimen with melphalan-busulfan and fludarabine (MBF) achieved low relapse rate in patients with acute myeloid leukemia (AML) and myelodysplasia syndrome (MDS). In our previous retrospective study, we demonstrated that melphalan dose at 100 or 140mg/m2 had similar incidence of relapse but it might had lower toxicities. In this prospective randomize study, we aim to compare the transplantation outcome in adult patients with AML/MDS receiving either MBF with 100 or 140 mg/m2 melphalan.
Detailed description
Intensity of conditioning regimen plays a important role in allogeneic stem cell transplantation (allo-HSCT) for patents with AML and MDS. IN our previous prospective study, we demonstrated that condoning regimen of dual alkylating agents with melphalan-busulfan and fludarabine (MBF) achieved a very low relapse rate (\~6%) in patients with acute myeloid leukemia (AML) and myelodysplasia syndrome (MDS). In that study, adult patients received melphalan 140mg/m2 while patients \>=60 or with high transplantation risk in terms of HCT-CI received reduced dose of melphalan (100mg/m2). Overall, it was shown that 100 or 140mg/m2 melphalan had similar incidence of relapse while the 100mg/m2 melphalan presented lower incidence of toxicities.In this prospective randomize study, we aim to compare the transplantation toxicities and outcomes in young adults (18\~55) with AML/MDS receiving either 100 or 140 mg/m2 melphalan as conditioning regimen.
Interventions
- Drug melphalan
conditioning regimen with melphalan, busulfan and fludarabine
Primary outcome measures
- Toxicities [Time frame: up to 100 days]
Secondary outcome measures (5)
- Relapse [Time frame: 2 years]
- Non-relapse mortality [Time frame: 100 days]
- Non-relapse mortality [Time frame: 2 years]
- disease-free survival [Time frame: 2 years]
- overall survival [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- Patients with AML in first remission
- Patients with MDS with bone marrow blast >5% but remain less than 20% before transplantation
- Donor available: HLA matched sibling donor, 9\~10/10 matched unrelated donor or haplo-identical donor
- Inform consent provided
Exclusion criteria
- Patients with active infection (bacteria, fungal or viral)
- Patients with abnormal liver, renal and cardiac function
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
China · 2 centers
- Rui Jin Hospital — Shanghai
- Zhaxin Hospital, Go Broad Health Care — Shanghai
Identifiers
NCT: NCT06829472 · MBF-RJH-2023