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Recruiting NCT06826794

VentilO Prospective Study

No phase Interventional Mechanical Ventilation Complication Respiratory Acidosis

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An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Clinicians, VenitlO.
Who it may be relevant to
Registry conditions: Mechanical Ventilation Complication, Respiratory Acidosis. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Canada
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Frequency of Respiratory Acidosis in the Intensive Care Unit After Postoperative Cardiac Surgery. Impact of Using VentilO Application

Overview

This is a randomized, open-label study comparing intial settings made by clinicians with settings recommandation made by the VentilO application immediately after intensive care unit admission.The study will allow direct comparison of the frequency of acidosis when patients are ventilated using the parameters of the VentilO application versus parameters chosen by the clinician. The variables determined by the clinician or VentilO will be respiratory rate, tidal volume and resulting minute ventilation.

Interventions

  • Other Clinicians
    Clinicians will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit.
  • Device VenitlO
    VentilO application (or web platerform) will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit.

Primary outcome measures

  • Respiratory acidosis [Time frame: 20 minutes after initiation of mechanical ventilation]
Secondary outcome measures (1)
  • Acid-base disorders on arrival in intensive care [Time frame: 5 minutes after initiation of mechanical ventilation]

Eligibility criteria

Inclusion criteria

  • Adults (> 18 years old)
  • Intubated patients admitted to intensive care immediately post-operatively after cardiac surgery (all cardiac surgery combined)
  • Ventilation in controlled mode (Assist Control or SIMV)

Exclusion criteria

  • Absence of anthropometric data (height and weight) of patients available in the patient file
  • Respiratory cycles mainly spontaneous on arrival
  • Patient extubated on arrival in intensive care

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Other

Study locations

Canada · 1 center
  • Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval — Québec

Publications

  • Roch R, Bouchard PA, Couture E, Lellouche F. Patient-Centered Ventilator Settings to Reduce Respiratory Acidosis After Cardiac Surgery. Respir Care. 2026 Apr;71(4):366-374. doi: 10.1177/19433654251412340. Epub 2026 Feb 19. PMID 41711585

Identifiers

NCT: NCT06826794 · 2025-4300

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗