The Effect of Hydration on Postprandial Metabolic Responses
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Water intake, Water restriction.
- Who it may be relevant to
- Registry conditions: Glycaemia. Basic parameters: 18 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Certain populations, such as industrial workers and endurance athletes are particularly susceptible to dehydration due to exposure to heat for long periods of time causing evaporative water loss via sweating. The physical and cognitive decrements associated with dehydration have been widely researched, however the effect of dehydration on metabolism is lesser known. As climate change is causing temperatures to rise, and metabolic diseases such as type 2 diabetes are more common, the effect of dehydration on metabolism, specifically glycemic response to meals, needs to be established for future recommendations in clinical, environmental and athletic settings. Therefore, the aim of this study is to investigate the effect of acute exercise-induced dehydration on subsequent metabolic responses to feeding (i.e. glycaemia and insulinaemia).
Interventions
- Other Water intake
Water ingested to fully replace sweat losses during exercise. - Other Water restriction
Water restriction to induce hypohydration of \~3% body mass through sweat losses during exercise.
Primary outcome measures
- Plasma glucose [Time frame: 6 hours]
Secondary outcome measures (11)
- Plasma insulin [Time frame: 6 hours]
- Plasma osmolality [Time frame: 6 hours]
- Plasma volume change [Time frame: 6 hours]
- Urine volume [Time frame: 6 hours]
- Body mass [Time frame: 6 hours]
- Urine specific gravity/osmolality [Time frame: 6 hours]
- Thirst sensation [Time frame: 6 hours]
- Hunger sensation [Time frame: 6 hours]
- Fullness sensation [Time frame: 6 hours]
- Core body temperature [Time frame: 6 hours]
- Blood pressure [Time frame: 6 hours]
Eligibility criteria
Inclusion criteria
- Male or female
- Generally fit and healthy
- Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week
Exclusion criteria
- < 18 or > 45
- Any health condition that may affect study outcomes (e.g., endocrine/liver/renal/cardiovascular disease)
- Any morbidity that affects ability to cycle
- Smoker or vaper
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United Kingdom · 1 center
- Loughborough University — Loughborough
Identifiers
NCT: NCT06825962 · 2025-20370