Residual Gastric Content and GLP-1
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Pre-op Gastric Emptying. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Studies have shown that even following the fasting guideline, patients on GLP-1 still have residual gastric content which increases their risk of aspiration during anesthesia. We aim to investigate the prevalence of full stomachs following different fasting times.
Detailed description
Glucagon-like peptide-1 (GLP-1) receptor agonists have become increasingly popular as both diabetic and weight loss therapies. One effect of this class of medication is delayed gastric emptying, which may impact the risk of aspiration during anesthesia delivery. Some of them have a very long half-life of approximately one week. Thus, it takes approximately five weeks to achieve its steady-state concentration, and just as long for its effects to terminate after stopping the drug.
As a standard of care, patients are allowed to drink up to 2 hours and to eat up to 8 hours before surgery. Studies have shown that even following the fasting guideline, patients still have residual gastric content which increases their risk of aspiration during anesthesia. Since stopping these drugs for a long time is not practical as it is going to disrupt their glycemic control and reverse the weight loss, we propose to test extending the fasting time.
We aim to investigate the prevalence of full stomachs following different fasting times.
patients will be assigned to one of three groups: Group 1(G1) with 8-hour fasting, Group 2 (G2) with 10-hour fasting, and Group 3 (G3) groups with 12-hour fasting
Primary outcome measures
- Prevalence of full stomach or residual gastric content in the 3 groups [Time frame: 8 hours]
- Prevalence of full stomach or residual gastric content in the 3 groups [Time frame: 10 hours]
- Prevalence of full stomach or residual gastric content in the 3 groups [Time frame: 12 hours]
Eligibility criteria
Inclusion criteria
Age ≥ 18 yr. ASA physical status I- III Elective surgery
Exclusion criteria
- Pregnancy
- History of upper gastrointestinal disease or previous surgery on the esophagus, stomach or upper abdomen;
- Documented abnormalities of the upper gastrointestinal tract such as gastric tumors; recent upper gastrointestinal bleeding (within the preceding 1 month).
- Medicines that may delay gastric emptying (e.g., anticholinergic agents, opioid)
- ASA class IV or above
- Unable to understand English
- Cardiac cases with low ejection fraction
- Elderly patients above 65 years of age
- Liver or renal transplant cases
- Type 1 diabetes Patients on insulin or sulphonylurea medication
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- University of Arkansas for Medical Science — Little Rock
Identifiers
NCT: NCT06814080 · 287139