The Ventilation During In-hospital Cardiac Arrest Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Positive pressure ventilation during cardiopulmonary resuscitation.
- Who it may be relevant to
- Registry conditions: Cardiac Arrest (CA), In-Hospital Cardiac Arrest, Heart Arrest. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Denmark, Norway
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study
Overview
The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients. The main questions it aims to answer are: What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC? Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.
Interventions
- Other Positive pressure ventilation during cardiopulmonary resuscitation
The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation. Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.
Primary outcome measures
- Fraction of patients with return of spontaneous circulation (ROSC) [Time frame: ROSC is assessed immediately following cardiopulmonary resuscitation.]
Secondary outcome measures (1)
- Fraction of patients surviving until day 30 [Time frame: Assessed at day 30 after cardiac arrest.]
Eligibility criteria
Inclusion criteria
- In-hospital cardiac arrest
- Age ≥ 18 years
- >1minute of recorded ventilation data
Exclusion criteria
- Documented do-not-attempt cardiopulmonary resuscitation order
- Invasive mechanical circulatory support at the time of the cardiac arrest
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Denmark · 10 centers
- Hospital of Southern Jutland - Aabenraa — Aabenraa
- Aalborg University Hospital — Aalborg
- Aarhus University Hospital — Aarhus
- Hospital of Southwest Jutland - Esbjerg — Esbjerg
- Gødstrup Hospital — Gødstrup
- North Denmark Region Hospital - Hjørring — Hjørring
- Horsens Regional Hospital — Horsens
- Odense University Hospital — Odense
- … and 2 more centers
Norway · 1 center
- St. Olavs Hospital, Trondheim University Hospital — Trondheim
Identifiers
NCT: NCT06809309 · VENT-IHCA · 1-16-02-301-24 · 2022-0367531