Orexin Gene in Anorexia Nervosa
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Blood samples and Questionnaires.
- Who it may be relevant to
- Registry conditions: Anorexia Nervosa. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Methylation Level of the Orexin Gene in Anorexia Nervosa: Relationship With Eating Disorder, Depressive State, and Sleep Quality
Overview
The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.
Interventions
- Other Blood samples and Questionnaires
Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire
Primary outcome measures
- Orexin A promoter methylation [Time frame: Baseline]
- Orexin B promoter methylation [Time frame: Baseline]
Eligibility criteria
Patients with Anorexia Nervosa:
Inclusion criteria
- Female sex
- Age 18 years and older
- Anorexia Nervosa
- Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy
Exclusion criteria
- Absence of signed informed consent
Control group:
Inclusion criteria
- Female sex
- Age 18 years and older
- Body Mass Index between 18.5 and 24.9 kg/m2
Exclusion criteria
- Absence of signed informed consent
- Presence of any physical and mental pathology
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Italy · 1 center
- Istituto Auxologico Italiano IRCCS, Site Piancavallo — Oggebbio
Identifiers
NCT: NCT06800898 · 01C414