Comparison of the Efficacy of Chemical Genicular Nerve Neurolysis Using Alcohol or Phenol Versus Radiofrequency Ablation Under Ultrasound Guidance for Pain Management in Patients With Knee Osteoarthritis
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: radiofrequency ablation, phenol neurolysis, alcohol neurolysis.
- Who it may be relevant to
- Registry conditions: Assessment of Pain Intensity Using 10-point Numerical Rating Scale (NRS-10)(9)Immediately After Intervention , 1 Week,1month,3 Months,6months and One Year, Assessment of Knee Function Using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Osteoarthritis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Chronic knee pain is a common condition that affects many people, particularly those with knee osteoarthritis. It can limit mobility, reduce the quality of life, and increase the risk of falling . There are various treatment options for chronic knee osteoarthritis pain, including medications, physical therapy and surgery. Topical and oral analgesic medications and physical therapy, are often used in this population but with variable success and often wanting pain relief over time as the condition progresses. Patients who fail medical treatment often undergo total knee arthroplasty (TKA) However, there are significant comorbidities associated with TKA, and most of patients suffer with chronic knee pain after this surgery Furthermore, a subset of patients are unable to undergo TKA because of medical comorbidities. One alternative treatment option is genicular nerve ablation, which involves destroying nerves that carry pain signals from the knee joint to the brain. Genicular nerve ablation can be performed using radiofrequency ablation (RFA) or chemical agents such as phenol. Both methods aim to provide long-term pain relief and functional improvement in patients with chronic knee pain(4). Chemical neurolytics, such as alcohol or phenol, have come to the fore because of their low cost and ease of application compared to radiofrequency ablation.These methods can be easily applied with ultrasound (US) guidance, which allows precise targeting of the relevant nerves. However, there is a lack of literature on appropriate agents and dose selection issues . Radiofrequency neurolysis (RFN) of the genicular nerves, which provides innervation to the capsule of the knee joint, as well as to the intra-articular and extra-articular ligaments, have been of considerable interest as an effective technique to alleviated knee osteoarthritis pain .However, it requires expensive specialized equipment and trained personnel, which may not be available or affordable in some settings.
Interventions
- Device radiofrequency ablation
35 Patients will be undergo for radiofrequency ablation which will be applied to each genicular nerve. - Drug phenol neurolysis
35 Patients will be administered with 2.0 ml of 6% phenol solution prepared from crystallized phenol per genicular nerve - Drug alcohol neurolysis
35 Patients will be administered with 1.0ml of 70% alcohol per genicular nerve
Primary outcome measures
- Assessment of pain intensity using 10-point numerical rating scale (NRS-10) [Time frame: immediately after intervention , 1 week,1month,3 months,6months and one year.]
Secondary outcome measures (2)
- Assessment of Knee function using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) [Time frame: immediately after intervention , 1 week,1month,3 months,6months and one year.]
- 2- Assessment of the side effects and complications of these methods as (paresthesia, motor deficits, pain during application and increase in pain) [Time frame: immediately after intervention , 1 week,1month,3 months,6months and one year.]
Eligibility criteria
Inclusion criteria
- The following will be the criteria for inclusion, (105) patients older than 18 years with moderate to severe knee pain due to knee osteoarthritis (pain of intensity six or more on a numeric rating scale \[NRS\], persistent pain for more than six months, grade III or IV osteoarthritis in the radiological Kellgren-Lawrence (KL) classification (5-11), and failure to manage pain with conservative methods such as analgesics, intra-articular injection, and physical therapy.
Exclusion criteria
- • Patients' refusal to participate in the study.
- History of intra-articular injection within three months before or after the procedure.
- Coagulopathy and anticoagulant use.
- Systemic disease as: renal or hepatic insufficiency.
- Unable to communicate with the patient.
- Implantable device.
- Previous knee surgery.
- Knee pain due to causes other than knee osteoarthritis (such as meniscopathy, trauma, spine disorder).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06798038 · 36265MD337/12/24