Reliability of Multiple-Repetition-Maximum Tests in Patients with Cardiovascular Disease or Risk Factors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Heart Failure, Coronary Heart Disease (CHD), Atrial Fibrillation (AF), Diabetes Mellitus. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Agreement of the Estimated 1-Repetition-Maximum Between Two Multiple-Repetition-Maximum Tests with Different Weight in Patients with Cardiovascular Disease or Risk Factors
Overview
Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important. The gold standard to prescribe resistance training intensity or monitor longitudinal changes is the 1-Repetition-Maximum (1-RM) test. However, particularly for unexperienced individuals, this test may not be recommendable due to the high load and an increased risk of injuries. Alternatively, there are several published formulas to estimate the 1-RM based on a multiple-repetition-maximum (or repetition-to-failure) test. However, these formulas have been primarily tested in healthy individuals. Moreover, the reliability of the 1-RM estimation based on two tests with different submaximal weight is unknown. Therefore, the present study evaluates the agreement of the 1-RM estimation (based on different formulas) between two Multiple-RM tests with different weight in 50 patients with cardiovascular disease (heart failure, coronary heart disease, atrial fibrillation) or cardiovascular risk factors (type 2 diabetes, arterial hypertension).
Primary outcome measures
- Estimated 1-Repetition-Maximum [Time frame: cross-sectional study (day 1)]
Secondary outcome measures (2)
- Number of repetitions required to perform a valid Multiple-Repetition-Maximum test [Time frame: cross-sectional (day 1)]
- Adverse Events [Time frame: cross-sectional (day 1)]
Eligibility criteria
Inclusion criteria
- Age ≥ 50 years
- At least one of the following cardiovascular diseases / risk factors:
- Heart failure
- Coronary heart disease
- Atrial fibrillation
- Arterial hypertension
- Type 2 diabetes mellitus
- Clinically stable for ≥ 4 weeks
- Medical clearance to perform resistance training / strength testing
- Signed written informed consent
Exclusion criteria
- Pregnancy
- Acute infection
- Chronic joint inflammation
- Knee, hip, ankle, wrist, elbow or shoulder pain
- Known osteoporosis (T-value ≤ -2.5)
- Uncontrolled hypertension (≥160 mmHG systolic / ≥100 mmHG diastolic)
- Known cerebral or thoracic aneurysm
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06796582 · 2025-27-S-CB