ASSESSMENT of FRAILTY AS a PROGNOSTIC FACTOR for MORTALITY, DISABILITY, and QUALITY of LIFE AFTER ICU ADMISSION
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Frailty, Frailty At Older Adults. Basic parameters: from 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Between 30% and 40% of elderly patients (over 70 years old) who require hospitalization and treatment in Intensive Care Units (ICU) exhibit a state of frailty. This condition is associated with adverse prognostic factors such as increased in-hospital mortality, functional decline, and a deterioration in their long-term quality of life. Some frail elderly patients may require invasive mechanical ventilation (ventilator) as life support during the acute phase, which has also been linked to adverse prognostic outcomes. Additionally, frailty is common in patients with severe infections, with a high mortality rate, subsequent functional decline, and reduced quality of life following ICU admission.
Detailed description
This project focuses on evaluating the role of geriatric frailty (FG) as a crucial predictive factor in various clinical aspects of elderly patients requiring admission to intensive care units (ICUs). Below is a breakdown of the project's main objectives for clarity:
Frailty as a predictor of mortality:
Assess whether frailty is an independent marker that predicts mortality over different timeframes (short, medium, and long term) in elderly patients admitted to the ICU.
Frailty and functional disability:
Determine whether frailty is associated with the evolution of functional disability in the short, medium, and long term following ICU admission.
Frailty and quality of life:
Analyze whether frailty can predict changes in the quality of life of elderly patients after their stay in the ICU, considering the same timeframes (short, medium, and long term).
Impact on patients requiring invasive mechanical ventilation (IMV):
Evaluate the impact of frailty on mortality, functional evolution, and quality of life in elderly patients requiring IMV.
Study the role of frailty as a prognostic factor for complications related to weaning from mechanical ventilation (tracheostomy, prolonged ICU or hospital stay, readmissions, and disability).
Frailty and sepsis/septic shock:
Investigate whether frailty is an independent prognostic marker for mortality in elderly patients with sepsis or septic shock admitted to the ICU.
This comprehensive approach aims not only to identify frailty as a key risk factor but also to guide management strategies and clinical decision-making for this particularly vulnerable population. If you need further elaboration or scientific drafting, feel free to ask!
Primary outcome measures
- MORTALITY [Time frame: ONE YEAR]
Eligibility criteria
Inclusion criteria
- Elderly patients over 70 years of age requiring admission to ICU-semicritical units.
- Patients receiving at least one life-support intervention for more than 24 hours, including:
- Mechanical ventilation (invasive or non-invasive),
- Vasopressor or inotropic treatment,
- Requirement for acute renal replacement therapies for more than 24 hours,
Extracorporeal support such as:
Veno-Venous Extracorporeal Membrane Oxygenation (ECMO-VV), Veno-Arterial Extracorporeal Membrane Oxygenation (ECMO-VA).
Exclusion criteria
- Patients with an ICU stay of less than 72 hours.
- Patients with treatment limitations upon ICU admission, although an isolated "Do Not Resuscitate" (DNR) order is acceptable; life expectancy of less than 6 months.
- Absence of family members or caregivers available to provide medical history. Language barriers (non-Spanish speakers without access to medical translators).
- Structural neurological diseases requiring ICU admission, including stroke or spinal cord pathology.
- Patients for whom 12-month follow-up is anticipated to be unfeasible.
- Patients without consent authorization.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06793462 · PR(AG)348/2024