Role of Some Biochemical Indices for Prediction of Acute Kidney Injury in Intensive Care Unit Patients in Upper Egypt
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: biochemical indices.
- Who it may be relevant to
- Registry conditions: Acute Kidney Injury. Basic parameters: from 16 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
1. We will investigate the relation between the triglyceride-glucose index and the development of AKI in ICU. 2. To detect whether the TGI is a predictor of poor outcome (requirement of renal replacement therapy, or 14-day in-hospital mortality, and length of hospital stay) in ICU. 3. Compare TGL, Neutrophil-to-lymphocyte ratio, and clinical score (sequential organ failure assessment SOFA score) as predictors of poor outcome in ICU.
Detailed description
Acute kidney injury (AKI) is a common clinical syndrome with a broad aetiological profile. It complicates about 5% of hospital admissions and 30% of admissions to intensive care units (ICU). During last 20 years has been a significant change in the spectrum of severe AKI such that it is no longer mostly a single organ phenomenon but rather a complex multisystem clinical problem. mortality from AKI, when part of MOF, remains over 50%.
In the past few decades, the understanding of AKI has greatly improved, but early diagnosis remains a great challenge. The performance of traditional kidney function index and serum creatinine is very limited for the early diagnosis of acute kidney injury The triglyceride glucose index (TGI) has been suggested as a useful marker of insulin resistance. Previous studies have shown that TGI is associated with many diseases, but no study has examined the relationship between TGI and Aki .
the primary objective of the present study was to investigate the relationship between TGI and Aki.
Interventions
- Diagnostic test biochemical indices
some biochemical indices for prediction of Acute kidney Injury
Primary outcome measures
- TGI [Time frame: baseline]
Eligibility criteria
Inclusion criteria
- The selected patients will be with the following inclusion criteria:
Patients admitted to ICU within 24 hours
Exclusion criteria
- We will exclude those with any of the following:
- Patients diagnosed more than 24 hours.
- Patients with missing data of triglyceride or glucose.
- Patients \<18years old.
- patient with advanced liver disease and chronic kidney disease with or without dialysis
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- جامعة اسيوط — Asyut
Publications
- Birkelo BC, Pannu N, Siew ED. Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient. Clin J Am Soc Nephrol. 2022 May;17(5):717-735. doi: 10.2215/CJN.14181021. Epub 2022 Mar 15. PMID 35292532
Identifiers
NCT: NCT06791200 · prediction of AKI in icu