Rapid Prehospital ACcess to ECPR in Prague
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Extracorporeal cardiopulmonary resuscitation (ECPR).
- Who it may be relevant to
- Registry conditions: Out of Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Czechia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prehospital Extracorporeal Cardiopulmonary Resuscitation: A Pilot Study in Prague
Overview
A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA
Detailed description
The aim of this pilot prospective study is to assess the feasibility and effectiveness of a prehospital extracorporeal cardiopulmonary resuscitation (ECPR) system for refractory out-of-hospital cardiac arrest (OHCA) in Prague, compared to a historical cohort of in-hospital ECPR recipients from the Prague OHCA trial.
Interventions
- Other Extracorporeal cardiopulmonary resuscitation (ECPR)
Prehospital extracorporeal cardiopulmonary resuscitation (ECPR)
Primary outcome measures
- Time from collapse to ECPR [Time frame: Time from estimated collapse to start of VA ECMO flow (estimated range: 20-100 minutes)]
Secondary outcome measures (2)
- All cause survival at 30-days [Time frame: 30-days]
- Modified Rankin Scale at 30-days [Time frame: 30-days]
Eligibility criteria
Inclusion criteria
- Estimated age 18-70 years
- Refractory out-of-hospital cardiac arrest (3 unsuccessful defibrillations and/or at least 10 minutes of resuscitation in case of pulseless electrical activity)
- Witnessed cardiac arrest
- ECPR team available
- ECPR team alert within 20 minutes from the emergency call
Exclusion criteria
- Unwitnessed cardiac arrest
- Asystole
- ETCO2 less than 10 mmHg upon ECPR team arrival
- Known limitations of intensive care (Do Not Resuscitate - DNR status)
- Known severe neurological impairment prior to cardiac arrest (mRS 4-6)
- Suspected or known pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Czechia · 1 center
- General University Hospital in Prague — Prague
Identifiers
NCT: NCT06789978 · 134/23 S-IV