Milk Vs Wheat Protein Intake to Maximize Whole-body Protein Synthesis Rates in Healthy Older Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: MILK, WHEAT.
- Who it may be relevant to
- Registry conditions: Protein Metabolism. Basic parameters: 65 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Netherlands
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Dietary protein intake is essential for tissue renewal and growth. Current recommendations for protein intake are based on studies using egg protein as reference protein. Egg protein is an animal-based protein with a high quality. Protein quality is determined by the composition of (essential) amino acids and digestibility. Therefore, different proteins have a different quality. Due to the environmental crisis, an increasing number of people consumes more plant-based proteins. These plant-based proteins often have a lower protein quality compared to animal-based proteins. Therefore, the aim of this study is to investigate whether optimal protein intake depend on protein quality. The optimal protein intake of an animal-based protein with a high quality (milk) will be compared to the optimal protein intake of a plant-based protein with a low quality (wheat).
Interventions
- Other MILK
Drink containing amino acids in the composition of milk protein - Other WHEAT
Drink containing amino acids in the composition of wheat protein
Primary outcome measures
- Differences in protein intake to maximize whole-body protein synthesis rates in older adults based on consumption of milk protein or wheat protein [Time frame: From enrollment to the end of the study at 7 weeks]
Secondary outcome measures (4)
- Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in healthy older adults based on milk protein [Time frame: From enrollment to the end of the study at 7 weeks]
- The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on milk protein [Time frame: From enrollment to the end of the study at 7 weeks]
- The Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in older adults based on wheat protein [Time frame: From enrollment to the end of the study at 7 weeks]
- The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on wheat protein [Time frame: From enrollment to the end of the study at 7 weeks]
Eligibility criteria
Inclusion criteria
- Aged between 65-85 years
- BMI between 18.5-30 kg\*m\^-2
- Healthy, recreationally active (maximal one intensive exercise training per week)
- No physical limitations (i.e., able to perform all activities associated with daily living independently)
Exclusion criteria
- Smoking
- Diagnosed musculoskeletal disorders
- Use of any medications known to affect protein metabolism (i.e., corticosteriods, non-steroidal anti-inflammatories)
- Chronic use of gastic acid-suppressing medication or anti-coagulants
- Unstable weight over the last 3 months
- Diagnosed GI tract disorders or diseases
- Blood donation in the past 2 months
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
Netherlands · 1 center
- Maastricht University Medical Center+ — Maastricht
Identifiers
NCT: NCT06783075 · METC 24-051