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Recruiting NCT06781892

Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest

No phase Interventional Cardiac Arrest (CA)

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Anterior-lateral pad positioning, Anterior-posterior pad positioning, Double-sequential defibrillation.
Who it may be relevant to
Registry conditions: Cardiac Arrest (CA). Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Denmark
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest - A Randomized Clinical Trial

Overview

The "Strategies for Defibrillation during Out-of-Hospital Cardiac Arrest" (STRAT-DEFI) trial is an investigator-initiated, individually randomized, 3-group clinical trial comparing standard anterior-lateral pad positioning with anterior-posterior positioning and double sequential defibrillation during adult out-of-hospital cardiac arrest.

Interventions

  • Other Anterior-lateral pad positioning
    Defibrillation pads positioned anterior-lateral
  • Other Anterior-posterior pad positioning
    Defibrillation pads positioned anterior-posterior
  • Other Double-sequential defibrillation
    Combination of anterior-lateral and anterior-posterior pad positioning for a total of 4 pads and 2 shocks.

Primary outcome measures

  • Survival at 30 days [Time frame: 30 days after the cardiac arrest]
Secondary outcome measures (3)
  • Survival at 90 days [Time frame: 90 days after the cardiac arrest]
  • Favorable neurological outcome at 30 days [Time frame: 30 days after the cardiac arrest]
  • Favorable neurological outcome at 90 days [Time frame: 90 days after the cardiac arrest]

Eligibility criteria

Inclusion criteria

  • Out-of-hospital cardiac arrest
  • Age ≥ 18 years
  • ≥ 1 manual defibrillation attempt by emergency medical services
  • Shockable rhythm as the last known rhythm
  • Two manual defibrillators present on-site

Exclusion criteria

  • Blunt trauma, penetrating trauma, or burn injury suspected to be the cause of the cardiac arrest
  • Prior enrollment in the trial
  • Posterior pad placement not deemed possible by on-site clinician

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Denmark · 6 centers
  • Emergency Medical Services, the North Denmark Region — Aalborg
  • Danish Air Ambulance, Danish Regions — Aarhus N
  • Prehospital Emergency Medical Services, Central Denmark Region — Aarhus N
  • Copenhagen Emergency Medical Services, the Capital Region of Denmark — Ballerup Municipality
  • The Prehospital Center, Region Zealand — Næstved
  • Emergency Medical Services, the Region of Southern Denmark — Vejle

Identifiers

NCT: NCT06781892 · 00006

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗