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Recruiting NCT06781008

SWEtick - a Prospective Multicenter Study of Tick-borne Diseases in Sweden

— Observational Tick-Borne Diseases

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Tick-Borne Diseases. Basic parameters: from 1 year · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Sweden
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Emerging Tick-borne Diseases in Children and Adults in Sweden (SWEtick): a Prospective Multicenter Study for Improved Patient Management

Overview

The purpose of the SWEtick project is to increase the knowledge of the various clinical presentations of emerging tick-borne diseases (eTBD), to assess their importance for human health, to develop and validate laboratory methods for diagnosis of eTBD, and to develop recommendations for knowledge-driven management of patients with suspected eTBD within the Swedish healthcare system.

Primary outcome measures

  • EuroQoL-5 Dimension Questionnaire (EQ-5D) [Time frame: 6 months]
  • Visual Analogue Scale for Health (VAS) [Time frame: 6 months]

Eligibility criteria

Inclusion Criteria in TBD and Non-TBD groups:

  • Clinical suspicion of tick-borne disease (physician's assessment based on medical history, symptoms, clinical findings and sometimes laboratory results)

Exclusion criteria

  • Incapacitated to understand the study information and make decisions (adults and adolescents >15 years)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

Sweden · 12 centers
  • Department of Paediatrics — Falun
  • Department of Paediatrics, Eksjö Hospital — Eksjö
  • Department of Infectious Diseases, County Hospital Ryhov — Jönköping
  • Department of Paediatrics — Jönköping
  • Department of Infectious Diseases, Kalmar County Hospital — Kalmar
  • Department of Infectious Diseases — Uppsala
  • Department of Paediatrics — Uppsala
  • Department of Paediatrics — Örebro
  • … and 4 more centers

Publications

  • Henningsson AJ, Asgeirsson H, Hammas B, Karlsson E, Parke A, Hoornstra D, Wilhelmsson P, Hovius JW. Two Cases of Borrelia miyamotoi Meningitis, Sweden, 2018. Emerg Infect Dis. 2019 Oct;25(10):1965-1968. doi: 10.3201/eid2510.190416. PMID 31538916
  • Uhnoo I, Cars O, Christensson D, Nystrom-Rosander C. First documented case of human babesiosis in Sweden. Scand J Infect Dis. 1992;24(4):541-7. doi: 10.3109/00365549209052642. PMID 1411322
  • Eimer J, Fernstrom L, Rohlen L, Grankvist A, Loo K, Nyman E, Henningsson AJ, Haglund M, Hultqvist V, Sjowall J, Wenneras C, Schon T. Spiroplasma ixodetis Infections in Immunocompetent and Immunosuppressed Patients after Tick Exposure, Sweden. Emerg Infect Dis. 2022 Aug;28(8):1681-1685. doi: 10.3201/eid2808.212524. PMID 35876734
  • Bjoersdorff A, Berglund J, Kristiansen BE, Soderstrom C, Eliasson I. [Varying clinical picture and course of human granulocytic ehrlichiosis. Twelve Scandinavian cases of the new tick-borne zoonosis are presented]. Lakartidningen. 1999 Sep 29;96(39):4200-4. Swedish. PMID 10544585
  • Nilsson K, Elfving K, Pahlson C. Rickettsia helvetica in patient with meningitis, Sweden, 2006. Emerg Infect Dis. 2010 Mar;16(3):490-2. doi: 10.3201/eid1603.090184. PMID 20202426
  • Nilsson K, Lindquist O, Pahlson C. Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Lancet. 1999 Oct 2;354(9185):1169-73. doi: 10.1016/S0140-6736(99)04093-3. PMID 10513711
  • Wenneras C, Wass L, Bergstrom B, Grankvist A, Lingblom C. Ten years of detecting Neoehrlichia mikurensis infections in Sweden: demographic, clinical and inflammatory parameters. Eur J Clin Microbiol Infect Dis. 2024 Nov;43(11):2083-2092. doi: 10.1007/s10096-024-04909-5. Epub 2024 Aug 13. PMID 39136831
  • Quarsten H, Henningsson A, Krogfelt KA, Strube C, Wenneras C, Mavin S. Tick-borne diseases under the radar in the North Sea Region. Ticks Tick Borne Dis. 2023 Jul;14(4):102185. doi: 10.1016/j.ttbdis.2023.102185. Epub 2023 Apr 26. PMID 37116420

Identifiers

NCT: NCT06781008 · EPM 2022-05330-01

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗