Abdominal Muscle Volume and a Neuromuscular Blocking Agent
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: preoperative computed tomography.
- Who it may be relevant to
- Registry conditions: Neuromuscular Blockade. Basic parameters: 19 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- South Korea
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Relationship Between Muscle Mass in Preoperative Computed Tomography and a Neuromuscular Blocking Agent Dose Required for Maintaining Deep Neuromuscular Blockage: a Prospective Observational Study.
Overview
With the recent development of image analysis and artificial intelligence, it has become possible to measure the muscle volume from preoperative computed tomography (CT) images. Therefore, in this study, the investigators quantify the muscle volume from preoperative CT images and analyze the correlation with the dose of neuromuscular blocking agent, rocuronium, required for maintaining deep neuromuscular blockade.
Detailed description
Deep neuromuscular blockade improves the condition of surgeon's surgical field during the surgery and reduces the acute postoperative pain. The dosage of neuromuscular blocking agent has been usually administered according to the patient's actual body weight, but even with the same body weight, the ratio of muscle to fat varies from individual to individual, and there are many differences depending on age, gender, and exercise level.
Therefore, if the dose of neuromuscular blocking agent is administered according to actual body weight, additional doses may be required due to insufficient neuromuscular blockade, or excessive doses may occur. However, it was difficult to quantify the muscle mass, with the recent development of image analysis, it has become possible to measure the abdominal muscle volume from preoperative computed tomography (CT) images. Therefore, in this study, the investigators quantify the muscle volume from preoperative CT images and analyze the correlation with the dose of neuromuscular blocking agent, rocuronium, required for maintaining deep neuromuscular blockade.
Interventions
- Diagnostic test preoperative computed tomography
subject's muscle mass from preoperative computed tomography (CT) images.
Primary outcome measures
- muscle volume [Time frame: intraoperative period]
Eligibility criteria
Inclusion criteria
- Those who voluntarily agreed and signed the written consent form before participating in the study
- American Society of Anesthesiologists physical class (ASA class) 1-3
- Patients scheduled for elective colon surgery under general anesthesia
- Patients undergoing abdominal computed tomography for routine preoperative preparation
Exclusion criteria
- Pregnant women
- Decreased renal function (GFR<60mL/min/1.73m2).
- Patients taking drugs that affect deep neuromuscular blockade
- Patients with a history of neuromuscular and muscle disorders
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
South Korea · 1 center
- Seoul National University Bundang Hospital — Seongnam-si
Identifiers
NCT: NCT06769932 · B-2501-947-305