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Recruiting NCT06769672

Dual-task Training Combined With tDCS on Cognitive-motor Performance and Brain Activity in Stroke Patients

No phase Interventional Stroke Cortical Excitability

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: active tDCS with dual-task training, sham tDCS with dual-task training.
Who it may be relevant to
Registry conditions: Stroke, Cortical Excitability. Basic parameters: from 50 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Hong Kong
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

The Effect of Dual-task Training Combined With tDCS on Cognitive-motor Interference and Related Brain Activity in Stroke Patients

Overview

The purpose of this study is to evaluate tDCS combined with cognitive-motor training on dual-task interference during dual-task walking, dual-task foot pedaling and the corresponding alterations of brain activity.

Detailed description

In China, the prevalence of stroke increased by 106.0% (93.7-118.8) between 1990 and 2019, highlighting the persistent and substantial burden of this condition. Post-stroke recovery, particularly the ability to achieve community ambulation, plays a critical role in improving health-related quality of life. Effective community ambulation in daily life requires the ability to dual-task-namely, to perform concurrent tasks requiring attentional resources while maintaining walking function and balance. Emerging evidence suggests that stroke survivors face greater challenges in walking function and dual-task balance compared to their age-matched, able-bodied counterparts. For instance, when tasked with recalling a shopping list while walking, stroke patients exhibit a more pronounced decline in both walking speed and cognitive performance relative to control groups. Given the necessity for stroke survivors to reintegrate into the community, it is imperative to thoroughly investigate this phenomenon of cognitive-motor interference.

Interventions

  • Other active tDCS with dual-task training
    participants receive three 20-minute active tDCS treatment and three 60-minute COGMOTION dual-task exercise sessions per week for four consecutive weeks.
  • Other sham tDCS with dual-task training
    participants receive three 20-minute sham tDCS treatment and three 60-minute COGMOTION dual-task exercise sessions per week for four consecutive weeks.

Primary outcome measures

  • Dual-task gait speed [Time frame: Through study completion, an average of 1 year]
  • Dual-task cognitive performance [Time frame: Through study completion, an average of 1 year]
Secondary outcome measures (9)
  • Oxyhemoglobin concentration changes of the brain [Time frame: Through study completion, an average of 1 year]
  • Dual-task gait performance 1 [Time frame: Through study completion, an average of 1 year]
  • Dual-task gait performance 2 [Time frame: Through study completion, an average of 1 year]
  • Dual-task gait performance 3 [Time frame: Through study completion, an average of 1 year]
  • Dual-task cognitive performance 1 [Time frame: Through study completion, an average of 1 year]
  • Blood oxygenation level changes of the brain [Time frame: Through study completion, an average of 1 year]
  • Dual-task stride time [Time frame: Through study completion, an average of 1 year]
  • Dual-task cognitive performance 2 [Time frame: Through study completion, an average of 1 year]
  • Dual-task gait performance 4 [Time frame: Through study completion, an average of 1 year]

Eligibility criteria

Inclusion criteria

  • a diagnosis of stroke, stroke onset of more than 6 months,
  • aged 50 or more,
  • capable of following verbal and visual instructions,
  • having a Montreal Cognitive Assessment score ≥ 22,
  • able to walk for 10 meters with/without a mobility aid,
  • community-dwelling, unilateral stroke

Exclusion criteria

  • neurological disorders, gait-precluding pain or comorbidity,
  • receiving any formal rehabilitation training,
  • contraindications to exercise (e.g., unstable angina),
  • contraindications to fNIRS, MRI, and tDCS (e.g., brain skin injury, pacemaker, metal implants in the brain),
  • history of seizure or epilepsy,
  • color blindness.
  • unable to walk with/without a mobility aid while responsing stimulus by the remote control

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Treatment

Study locations

Hong Kong · 1 center
  • The Hong Kong Polytechnic University — Hong Kong

Identifiers

NCT: NCT06769672 · Marco PANG_tDCS

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗