Neural Changes in Stroke Patients During Challenging Walking Tasks.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: pedal walking, visual occlusion.
- Who it may be relevant to
- Registry conditions: Stroke. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Neural Mechanism Changes in Stroke Patients During Challenging Environments
Overview
For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery. Pedal walking and walking with eyes-covered are both difficult and challenging tasks for stroke patients. The investigators intend to study the biomechanics and neural mechanisms of challenging pedal walking and walking with eyes covered. Stroke participants will wear electroencephalogram electrode caps and perform three tasks: walking on a flat surface for 60 seconds, walking on pedal for 60 seconds, and walking with eyes covered for 60 seconds.
Detailed description
Stroke participants will wear a 32-lead electroencephalogram electrode cap (Zhentai Technology Company, Xi 'an, China), first walk on a flat ground for 60 seconds, rest for 2 minutes, then walk on the pedal for 60 seconds, rest again for 2 minutes, and walk for 60 seconds with eyes-covered.
Interventions
- Other pedal walking
Pedal walking is a challenging walking task that can be used as a form of physical therapy for stroke participants. - Other visual occlusion
Walking with eyes-covered is a challenging walking task that can be used as a form of physical therapy for stroke participants.
Primary outcome measures
- Weight Phase Lag Index [Time frame: The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds]
- Relative power [Time frame: The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds]
Eligibility criteria
Inclusion criteria
- First-time occurrence of stroke confirmed by computed tomography or magnetic resonance imagingClinical diagnosis of stroke
- Disease duration of more than 14 days， less than 1 year
- Able to walk independently but with a lingering abnormal gait
Exclusion criteria
- Lesions accumulate in the brainstem
- Lesions accumulate in the cerebellum
- Impaired vision
- Severe cognitive impairment
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 2 centers
- Geriatric Hospital of Nanjing Medical University, 269 Qingmen Street — Nanjing
- Geriatric Hospital of Nanjing Medical University — Nanjing
Publications
- Krakauer JW. Motor learning: its relevance to stroke recovery and neurorehabilitation. Curr Opin Neurol. 2006 Feb;19(1):84-90. doi: 10.1097/01.wco.0000200544.29915.cc. PMID 16415682
- Fettrow T, Hupfeld K, Tays G, Clark DJ, Reuter-Lorenz PA, Seidler RD. Brain activity during walking in older adults: Implications for compensatory versus dysfunctional accounts. Neurobiol Aging. 2021 Sep;105:349-364. doi: 10.1016/j.neurobiolaging.2021.05.015. Epub 2021 May 31. PMID 34182403
- Kulkarni A, Cui C, Rietdyk S, Ambike S. Humans prioritize walking efficiency or walking stability based on environmental risk. PLoS One. 2023 Apr 7;18(4):e0284278. doi: 10.1371/journal.pone.0284278. eCollection 2023. PMID 37027387
Identifiers
NCT: NCT06764290 · 2024018-1