Periodization Resistance Training on Quality of Life in Females With Hypothyroidism
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: non linear periodization exercise, linear periodization exercise, medical treatment.
- Who it may be relevant to
- Registry conditions: Hypothyroidism. Basic parameters: 35 years — 45 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Nonlinear Versus Linear Periodized Resistance Training on Quality of Life in Females With Hypothyroidism
Overview
This study will be conducted to compare between the effect of nonlinear and linear periodized training on quality of life in females with hypothyroidism.
Detailed description
Worldwide, the incidence of individuals with thyroid dysfunction is increasing and represents approximately 30-40% of the patients seen in an endocrine clinic; thus, it is one of the leading endocrine disorders.The undiagnosed thyroid dysfunction especially subclinical and clinical hypothyroidism may increase cardiovascular risk factors.
The prevalence of hypothyroidism depends on many factors, such as age, sex and geographical factors. It's also a diet related disorder and it's usually seen when the daily intake of iodine falls below 25μg.
Hypothyroidism tends to affect women more often than men and can manifest at any age, typically observed between 40 and 70 years. No specific racial predilection has been identified in studies regarding this condition. regular exercise can improve quality of life in patients with subclinical hypothyroidism by increasing physical activity level/fitness and reducing the signs and symptoms of the disease. Exercise may therefore potentiate the effectiveness of levothyroxine and help hypothyroid individuals improve their quality of life.
Periodization of resistance training or planned changes in training volume and intensity are used to maximize strength and fitness gains. The most common of periodized resistance training plans is linear also termed classic or strength/power periodization and nonlinear periodization. The biggest difference between these two types of training plans is with nonlinear periodization changes in training volume and intensity are made more frequently. The most common type of nonlinear periodization is daily nonlinear periodization where substantial changes in training intensity and volume are made from one training session to the next training session.
So, this study will be conducted to compare between the effect of non linear and linear periodized resistance training on quality of life in females with hypothyroidism.
Interventions
- Other non linear periodization exercise
The non-linear periodized resistance training program follows a 12-week schedule with varying intensity levels across three training days per week. The intensity fluctuates between very light (VL), light (L), moderate (M), heavy (H), and very heavy (VH) workouts, distributed strategically throughout the week. Each training day implements different intensity levels, and an active rest day follows any workout session. - Other linear periodization exercise
The linear periodization exercise program spans 12 weeks with systematically varied training parameters. During weeks 1-2, participants perform 3 sets of 10 repetitions, followed by 3 sets of 8 repetitions in weeks 3-4. The program progresses to 4 sets of 6 repetitions in weeks 5-6, then 3 sets of 6 repetitions during weeks 7-8. The final phases consist of 4 sets of 4 repetitions in weeks 9-10, concluding with 3 sets of 4 repetitions in weeks 11-12. Training loads advance through autoregulatory - Drug medical treatment
The medical treatment will be received for 12 weeks.
Primary outcome measures
- Serum thyroid stimulating hormone (TSH) level [Time frame: 12 weeks]
- FreeT4 (thyroxine) level [Time frame: 12 weeks]
- Health related Quality of life questionnaire [Time frame: 12 weeks]
Secondary outcome measures (3)
- Triglyceride-glucose (TyG) index [Time frame: 12 weeks]
- Hand grip strength [Time frame: 12 weeks]
- 9-item Fatigue Severity Scale (FSS) [Time frame: 12 weeks]
Eligibility criteria
Inclusion criteria
- Be controlled hypothyroidism (TSH level within 0.5 - 4.5 mU/L)
- Be ranged from 35 to 45 years
- Female patients
- Body Mass Index 30-34.9 kg/m2 .
- triglyceride-glucose (TyG) index > 4.5
Exclusion criteria
- history of pulmonary disease
- Patients with uncontrolled coronary or cerebrovascular disease
- Those who underwent musculoskeletal surgery within the previous year
- Recent history of lower and upper limb fracture , hip and shoulder dislocation.
- Cognitive impaired patients
- Patients with history of epilepsy
- Patients who participating in any other exercise program
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Suez University — Suez
Identifiers
NCT: NCT06757712 · P.T.REC/012/005442