Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Curcumin with photodynamic thearpy, Control group.
- Who it may be relevant to
- Registry conditions: Periapical Diseases, Postoperative Dental Pain, Irrigation Solution, Photodynamic Therapy (PDT). Basic parameters: 18 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Effect of Photodynamic Therapy Using Curcumin As a Photosensitizer on Postoperative Pain After Non-Surgical Root Canal Retreatment: a Randomized Controlled Clinical Trial
Overview
In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has been demonstrated in several studies. However, no research has specifically examined their effect on postoperative pain. The aim of this study is to investigate the impact of using a curcumin solution in combination with photodynamic therapy as the final irrigation solution on postoperative pain.
Detailed description
Fifty patients were randomly assigned to two groups using a web-based program, according to the selected final irrigation procedure: curcumin-photodynamic therapy or a control group (routine root canal final irrigation with NaOCl and EDTA). The teeth will be isolated with a rubber dam, and access cavities will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will then be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.
Interventions
- Other Curcumin with photodynamic thearpy
root canals will irrigated with final irrigation procedure: curcumin+photodynamic therapy. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms. - Other Control group
root canals will irrigated with routine root canal final irrigation with NaOCl and EDTA. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.
Primary outcome measures
- postoperative pain levels [Time frame: one week]
Secondary outcome measures (4)
- dependent variables-sex [Time frame: one week]
- dependent variable-age [Time frame: one week]
- dependent variables-teeth number [Time frame: one week]
- dependent variables-smoking habit [Time frame: one week]
Eligibility criteria
Inclusion criteria
- healthy patients with aged between 18-60.
- Incisor, canine, and premolar teeth that had previously undergone root canal treatment
- Incisor, canine, and premolar teeth with a diagnosis of chronic apical abscess or asymptomatic apical periodontitis
- teeth with only 1 root canal
- the patients had not used any antibiotics for 3 months before treatment
Exclusion criteria
- the presence of a root fracture
- teeth with any swelling
- ankyloses,
- periodontal pockets deeper than 4 mm.
- teeth which a rubber dam could not be performed
- patients with allergy to ibuprofen or ciprofloxacin were also excluded.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Turkey (Türkiye) · 1 center
- Atatürk University — Erzurum
Identifiers
NCT: NCT06752655 · 404380