DAANCE FOR CHEMOTHERAPY-INDUCED NEUROPATHY
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Tango.
- Who it may be relevant to
- Registry conditions: Cancer of the Breast, Chemotherapy-induced Neuropathy. Basic parameters: from 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
DANCE-BASED AVENUES TO ADVANCE NONPHARMACOLOGIC TREATMENT OF CHEMOTHERAPY EFFECTS (DAANCE): A MULTICENTER TRIAL
Overview
Up to 80% of breast cancer survivors experience chemotherapy-induced neuropathy that impairs quality of life and increases fall risk long into survivorship, yet treatment options for neuropathy remain limited. The successful treatment will target neurophysiologic mechanisms for restoring function while addressing patient-reported symptoms and participation in treatment. Toward this end, the investigators propose to study a noninvasive, social sensorimotor intervention - Adapted Argentine Tango - which targets motor control restoration, symptom alleviation, and treatment participation in concert.
Detailed description
This study will investigate a noninvasive, social, sensorimotor intervention which targets motor control restoration, symptom alleviation, and treatment participation in concert: partnered Adapted Argentine Tango (Tango). This project will expand the investigators' pilot work (R21-AG068831) into a multicenter clinical trial designed to investigate the effect of social dance on sensory relief, functional restoration, and key mechanisms of action among a diverse cohort of BC survivors suffering from chronic chemotherapy-induced sensorimotor deficits.
Interventions
- Behavioral Tango
The intervention being studied is a 16 session intervention (2x4-week modules), delivered over an 8-week period by community-based individuals with expertise in dance and patient care and certified in Adapted Tango or AdapTango dance instruction. Steps available to teach, including order and cues to teach them, are detailed in Hackney's AdapTango manual. All steps are based on the Argentine Tango steps that emerged within working class community centers in Buenos Aires, Argentina (milongas) in t
Primary outcome measures
- Patient-Reported Outcome (PRO) - CIN sensation [Time frame: 4 weeks]
- Dual-task function [Time frame: 4 weeks]
Secondary outcome measures (12)
- Patient-Reported Outcome (PRO) - hot/cold sensation [Time frame: 4 weeks; 8 weeks; 12 weeks]
- EORTC-CIPN 20 [Time frame: mid-intervention (4weeks); post -intervention (8 weeks); 1 month follow up post intervention]
- Brief Fatigue Inventory [Time frame: 4 weeks; 8 weeks; 12 weeks]
- Brief Pain Inventory [Time frame: 4 weeks; 8 weeks; 12 weeks]
- Patient Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) [Time frame: 4 weeks; 8 weeks; 12 weeks]
- Physical Health Questionnaire-2 (PHQ-2) [Time frame: 4 weeks; 8 weeks; 12 weeks]
- Generalized Anxiety Questionnaire [Time frame: 4 weeks; 8 weeks; 12 weeks]
- Falls [Time frame: 4 weeks; 8 weeks; 12 weeks; 6 months following intervention end]
- The Mini Balance Evaluation Systems Test (MiniBEST) [Time frame: 4 weeks (Control group); 8 weeks (Intervention group)]
- Biomechanical measures of postural control [Time frame: 4 weeks; 8 weeks; 12 weeks]
- Six minute walk test (6mwt) [Time frame: 4 weeks; 8 weeks]
- Gait stability [Time frame: 4 weeks; 8 weeks]
Eligibility criteria
Inclusion criteria
- Breast Cancer (BC) diagnosis of Stage I-IV including metastatic disease
- completed taxane-based chemotherapy for BC at least 3 months ago (no limit on how long ago)
- symptomatic for chemotherapy-induced neuropathy (self-report)
- postural control score that indicates potential fall-risk
- able to understand and comply with directions associated with testing and study treatments
Exclusion criteria
- pre-existing vestibular dysfunction
- poorly controlled diabetes (hgA1C>=8)
- non-ambulatory (assistive and prosthetic devices allowed)
- hearing impairment resulting in less than 10% hearing bilaterally
- contraindication to participate in the experimental physical activity per the treating oncologist due to additional condition (e.g., herniated disc, unstable bone metastases)
- currently in activity-based therapy (e.g., physical therapy, occupational therapy). May enroll if still meet eligibility criteria once activity-based therapy is complete.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Supportive care
Study locations
United States · 2 centers
- Yale University — New Haven
- The Ohio State University — Columbus
Publications
- Worthen-Chaudhari L, Bing J, Schmiedeler JP, Basso DM. A new look at an old problem: defining weight acceptance in human walking. Gait Posture. 2014;39(1):588-92. doi: 10.1016/j.gaitpost.2013.09.012. Epub 2013 Sep 28. PMID 24139684
- Worthen-Chaudhari L, Schnell PM, Hackney ME, Lustberg MB. Partnered dance evokes greater intrinsic motivation than home exercise as therapeutic activity for chemotherapy-induced deficits: secondary results of a randomized, controlled clinical trial. Front Psychol. 2024 Jun 19;15:1383143. doi: 10.3389/fpsyg.2024.1383143. eCollection 2024. PMID 38962217
- Worthen-Chaudhari LC, Crasta JE, Schnell PM, Lantis K, Martis J, Wilder J, Bland CR, Hackney ME, Lustberg MB. Neurologic dance training and home exercise improve motor-cognitive dual-task function similarly, but through potentially different mechanisms, among breast cancer survivors with chemotherapy-induced neuropathy: Initial results of a randomized, controlled clinical trial. J Alzheimers Dis. PMID 39584292
- Worthen-Chaudhari L, Lamantia MT, Monfort SM, Mysiw W, Chaudhari AMW, Lustberg MB. Partnered, adapted argentine tango dance for cancer survivors: A feasibility study and pilot study of efficacy. Clin Biomech (Bristol). 2019 Dec;70:257-264. doi: 10.1016/j.clinbiomech.2019.08.010. Epub 2019 Aug 22. PMID 31751861
- Worthen-Chaudhari LC, Monfort SM, Bland C, Pan X, Chaudhari AMW. Characterizing within-subject variability in quantified measures of balance control: A cohort study. Gait Posture. 2018 Jul;64:141-146. doi: 10.1016/j.gaitpost.2018.05.031. Epub 2018 Jun 2. PMID 29908434
- Mezzanotte JN, Grimm M, Shinde NV, Nolan T, Worthen-Chaudhari L, Williams NO, Lustberg MB. Updates in the Treatment of Chemotherapy-Induced Peripheral Neuropathy. Curr Treat Options Oncol. 2022 Jan;23(1):29-42. doi: 10.1007/s11864-021-00926-0. Epub 2022 Feb 15. PMID 35167004
- Luciani BD, Alwan A, Carlson M, McNally G, Hackney ME, Crasta JE, Schnell P, Lustberg MB, Worthen-Chaudhari L. Dance-based avenues to advance nonpharmacologic treatment of chemotherapy effects (DAANCE): study protocol for a multi-center, randomized controlled trial. Trials. 2026 Feb 21;27(1):246. doi: 10.1186/s13063-026-09486-w. PMID 41723535
- Luciani B, Carlson M, McNally G, Hackney ME, Crasta JE, Schnell P, Lustberg MB, Worthen-Chaudhari L. Dance-based avenues to advance nonpharmacologic treatment of chemotherapy effects (DAANCE): Study protocol for a multi-center, randomized controlled trial. Res Sq [Preprint]. 2025 Jul 7:rs.3.rs-6814353. doi: 10.21203/rs.3.rs-6814353/v1. PMID 40671809
Identifiers
NCT: NCT06749210 · OSU-24277 · R01AG084676 · OSU-24277